| Title: |
Parameters defining the potential applicability of Raman spectroscopy as a diagnostic tool for oral disease. |
| Authors: |
Kevin Guze, Michael Short, Stephen Sonis, Nadeem Karimbux, Jimmy Chan, Haishan Zeng |
| Source: |
Journal of Biomedical Optics; Jan2009, Vol. 14 Issue 1, p14016-14016, 1p |
| Subject Terms: |
MUCOUS membranes, BIOLOGICAL membranes, MULTICULTURALISM, ORAL mucosa |
| Abstract: |
Raman spectroscopy can provide information about the molecular composition of tissues, with potential to be applied as a diagnostic tool in lieu of histopathology. Our objectives are to determine if laser Raman spectra (RS) can be acquired reliably from the oral mucosa of patients, and to determine if the RS signature of normal oral mucosa is reproducible among anatomic oral sites and among subjects of different races and gender. 25 Caucasian and 26 Asian subjects are studied using RS with a signal acquisition time of 1 sat seven specified sites within the mouth. Multivariate analysis is used to determine the variability between tissue types and between races and gender. Unique spectra are defined for various sites in the mouth and are likely related to the degree of keratinization. However, spectral concordance by site is not greatly influenced by subject ethnicity or gender. We demonstrate, for the first time, the potential in-vivoapplication of RS for oral mucosal disease and demonstrate its specificity for particular mucosal types in the mouth. RS offers the potential to provide a diagnosis of disease using a noninvasive, convenient, sensitive technology that provides immediate results. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Biomedical Optics is the property of SPIE - International Society of Optical Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
