Bibliographic Details
| Title: |
Renin-Angiotensin System Gene Polymorphisms and Atrial Fibrillation: A Regression Approach for the Detection of Gene-Gene Interactions in a Large Hospitalized Population. |
| Authors: |
Chia-Ti Tsai, Juey-Jen Hwang, Fu-Tien Chiang, Yi-Chih Wang, Chuen-Den Tseng, Yung-Zu Tseng, Jiunn-Lee Lin |
| Source: |
Cardiology; 2008, Vol. 111 Issue 1, p1-7, 7p, 4 Charts |
| Subject Terms: |
RENIN-angiotensin system, GENETIC polymorphisms, ANGIOTENSIN converting enzyme, ATRIAL fibrillation, ANGIOTENSINS |
| Abstract: |
Objectives: To test the association between renin-angiotensin system gene variants and atrial fibrillation (AF) using a regression approach. Methods: A total of 1,236 consecutive patients (227 with AF and 1,009 with normal sinus rhythm as controls) were recruited. Angiotensin-converting enzyme (ACE) gene I/D polymorphism; T174M, M235T, G–6A, A–20C, G–152A and G–217A polymorphisms of the angiotensinogen (AGT) gene, and A1166C polymorphism of the angiotensin II type I receptor (AT1R) gene were genotyped. We used a regression approach based on a generalized linear model to evaluate haplotype effects and to detect gene-gene interactions by incorporating interaction terms in the model. Results: In single-locus analyses, no locus was associated with AF. After adjustment for AF risk factors, we found significant differences in the global AGT gene haplotype profile (the global score statistic = 30.364, p = 0.001) and individual haplotype frequencies between AF patients and controls. Furthermore, significant 2-way gene-gene interactions between ACE I/D polymorphism and AGT gene haplotypes and between AT1R A1166C polymorphism and AGT gene haplotypes, and 3-way interaction between ACE I/D, AT1R A1166C and AGT gene haplotypes were detected. Conclusions: These results are compatible with the concept of multilocus and multigene effects in determining the risk of complex diseases such as AF, which would be missed with conventional single-locus approaches. Copyright © 2008 S. Karger AG, Basel [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
