| Title: |
DCDC2 is associated with reading disability and modulates neuronal development in the brain. (English) |
| Authors: |
Haiying Meng, Smith, Shelley D., Hager, Karl, Held, Matthew, Liu, Jonathan, Olson, Richard K., Pennington, Bruce F., DeFries, John C., Gelernter, Joel, O'Reilly-Pol, Thomas, Somlo, Stefan, Skudlarski, Pawel, Shaywitz, Sally E., Shaywitz, Bennett A., Marchione, Karen, Yu Wang, Paramasivam, Murugan, LoTurco, Joseph J., Page, Grier P., Gruen, Jeffrey R. |
| Source: |
Proceedings of the National Academy of Sciences of the United States of America; 11/22/2005, Vol. 102 Issue 47, p17053-17058, 6p |
| Subject Terms: |
BIOCHEMISTRY, NUCLEIC acids, RNA, BRAIN research, NEURAL stem cells, DIAGNOSTIC imaging |
| Abstract: |
DYX2 on 6p22 is the most replicated reading disability (RD) locus. By saturating a previously identified peak of association with single nucleotide polymorphism markers, we identified a large polymorphic deletion that encodes tandem repeats of putative brain-related transcription factor binding sites in intron 2 of DCDC2. Alleles of this compound repeat are in significant disequilibrium with multiple reading traits. RT-PCR data show that DCDC2 localizes to the regions of the brain where fluent reading occurs, and RNA interference studies show that down-regulation alters neuronal migration. The statistical and functional studies are complementary and are consistent with the latest clinical imaging data for RD. Thus, we propose that DCDC2 is a candidate gene for RD. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
