Bibliographic Details
| Title: |
A case report of carboxymethylcellulose allergy: exploring tolerance based on administration route. |
| Authors: |
Piotin, Anays, Poirot, Anh, Wurm, Maxence, Lutz, Celine, Khayath, Naji, de Blay, Frédéric, Metz-Favre, Carine |
| Source: |
Immunopharmacology & Immunotoxicology; Apr2025, Vol. 47 Issue 2, p234-238, 5p |
| Subject Terms: |
ORAL drug administration, MEDICAL personnel, EYE drops, FOOD allergy, FOOD additives |
| Abstract: |
Background: The management of hypersensitivity to excipients and food additives remains a significant issue for healthcare professionals and patients. Avoiding carboxymethylcellulose (CMC) can be a considerable challenge for patients allergic to CMC due to its widespread use. We assessed the tolerance of CMC through different route of administration in a patient with a confirmed CMC allergy. We conducted a literature review to analyze all relevant cases of patients allergic to CMC, focusing on tolerance through non-injectable routes. Methods: Skin tests, basophil activation tests, oral and nasal provocation tests with CMC were performed to evaluate patient's hypersensitivity. Results: Skin tests and basophil activation tests with CMC were positive and confirmed IgE-mediated hypersensitivity to CMC in the patient. While the patient tolerated oral administration of CMC and CMC-containing eye drops, nasal provocation test resulted in asthma exacerbation and rhinitis. Conclusion: Tolerance of CMC appears to be route-dependent. Provocation tests with CMC through various routes of administration are essential for assessing tolerance and providing appropriate recommendations for patients with CMC allergy. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
