Bibliographic Details
| Title: |
New Therapeutic Perspectives in Type B Insulin Resistance Syndrome: Efficacy of a Multitarget Therapy With Obinutuzumab and Mycophenolate Mofetil in Two Patients With Insulin Receptor Autoantibodies and Systemic Lupus Erythematosus. |
| Authors: |
Jachiet, Vincent, Vuillaume, Philippine, Hadjadj, Jérôme, Abisror, Noémie, Auclair, Martine, Fain, Olivier, Vigouroux, Corinne, Vatier, Camille |
| Source: |
Diabetes Care; Apr2025, Vol. 48 Issue 4, pe51-e53, 3p |
| Subject Terms: |
SYSTEMIC lupus erythematosus, AUTOIMMUNE diseases, IMMUNOTHERAPY, INSULIN antibodies, METABOLIC reprogramming, COMBINATION drug therapy, METABOLIC syndrome, MYCOPHENOLIC acid |
| Abstract: |
The article published in Diabetes Care discusses Type B insulin resistance syndrome (TBIRS), a rare autoimmune condition primarily affecting middle-aged women of African descent and often associated with systemic lupus erythematosus (SLE). The study reports the successful treatment of two patients with TBIRS and SLE using a multitarget therapy combining obinutuzumab and mycophenolate mofetil. The treatment led to significant metabolic improvements, cessation of insulin therapy, weight regain, and reduction in autoimmune markers, demonstrating the potential efficacy of this approach in managing this challenging condition. [Extracted from the article] |
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| Database: |
Complementary Index |
