Bibliographic Details
| Title: |
Cumulative influence of immunogenic factors, genetic variations, and protein modulations in subacute sclerosing panencephalitis (SSPE): A narrative review. |
| Authors: |
Pandey, Nikhil, Srivastava, Niraj Kumar, Kumar, Anand, Hussain, Ibrahim, Joshi, Deepika |
| Source: |
Neurology & Clinical Neuroscience; Mar2025, Vol. 13 Issue 2, p93-100, 8p |
| Subject Terms: |
MEASLES virus, DISEASE susceptibility, GENETIC variation, DISEASE progression, GENETIC markers |
| Abstract: |
Subacute sclerosing panencephalitis (SSPE) is a progressive and catastrophic neurodegenerative disorder due to persistent infection with the aberrant measles virus in the brain. The exact etiology of SSPE is still unknown, and early diagnosis remains a challenge, especially with the atypical presentations. The pathogenesis of SSPE involves a complex interplay between viral factors and immunological response of the host. The presenting review demonstrates an extensive glimpse of the immuno‐genetics of SSPE, exploring the single‐nucleotide polymorphisms (SNPs), genetic risk factors and immune responses that influence susceptibility and disease progression. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
