| Title: |
INVESTIGATION OF THE EFFECT OF PLA2R1 POLYMORPHISM IN PATIENTS WITH MEMBRANOUS NEPHROPATHY. |
| Alternate Title: |
MEMBRANÖZ NEFROPATİLİ HASTALARDA PLA2R1 POLİMORFİZMİNİN ETKİSİNİN ARAŞTIRILMASI. (Turkish) |
| Authors: |
ADIKOZALOVA, Aida, USTA AKGÜL, Sebahat, DEMİR, Erol, ŞENTÜRK ÇİFTCİ, Hayriye, SAVRAN OĞUZ, Fatma, YAZICI, Halil, KEKİK ÇINAR, Çiğdem |
| Source: |
Journal of Advanced Research in Health Sciences (JARHS) / Sağlık Bilimlerinde İleri Araştırmalar Dergisi (SABİAD); Oct2024, Vol. 7 Issue 3, p160-164, 5p |
| Abstract (English): |
Objective: Membranous nephropathy (MN) is the most common cause of nephrotic syndrome in adults. Phospholipase A2 receptor (PLA2R1) is a glycoprotein belonging to the mannose receptor family (~180 kDa). PLA2R1 was found to be associated with idiopathic MN pathogenesis, and the presence of PLA2R1 antibodies was supported by the diseases. In this study, the association of PLA2R1 rs35771982 with membranous nephropathy was investigated. Material and Methods: The study included 88 patients diagnosed with MN and 101 healthy individuals unrelated to the patients. The PLA2R1 rs35771982 levels of the patient and control groups were examined using the Real Time PCR (Polymerase Chain Reaction) method. Results: The comparison of the patients with healthy controls in this study showed that the rs35771982 GG genotype was significantly higher in the patients. The genotype of rs35771982 in the Turkish population was found to be common to the CG genotype. Conclusion: Our findings revealed that the PLA2R1 rs35771982 GG genotype is associated with susceptibility to MN. [ABSTRACT FROM AUTHOR] |
| Abstract (Turkish): |
Amaç: Membranöz nefropati (MN), erişkinlerde nefrotik sendromun en sık nedenidir. Fosfolipaz A2 reseptörü (PLA2R1), mannoz reseptör ailesine (~180 kDa) ait glikoproteindir. PLA2R1, idiyopatik MN patogenezi ile ilişkili bulunmuş, PLA2R1 antikorlarının varlığının hastalıkla ilişkisi desteklenmiştir. Bu çalışmada PLA2R1 rs35771982’nin Membranöz Nefropati ile ilişkisi araştırıldı. Gereç ve Yöntemler: Çalışmaya MN tanısı alan 88 hasta ve bu hastalarla ilişkisi olmayan 101 sağlıklı birey dahil edildi. Hasta ve kontrol gruplarının PLA2R1 rs35771982’si Real Time PCR (Polimeraz Zincir Reaksiyonu) yöntemi ile incelendi. Bulgular: Hastaları sağlıklı kontrollerle karşılaştırdığımızda rs35771982 GG genotipinin hastalarda anlamlı derecede yüksek olduğu görüldü. Türk popülasyonunda rs35771982 CG genotipinin yaygın olduğu bulundu. Sonuç: PLA2R1 rs35771982 GG genotipinin MN’ye duyarlılıkla ilişkili olduğu bulundu. [ABSTRACT FROM AUTHOR] |
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Copyright of Journal of Advanced Research in Health Sciences (JARHS) / Sağlık Bilimlerinde İleri Araştırmalar Dergisi (SABİAD) is the property of Journal of Advanced Research in Health Sciences (JARHS) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
