Bibliographic Details
| Title: |
An Observational Study to Determine the Prevalence of COVID-19 Among Hospitalized Patients With Multidrug-Resistant Enterobacterales Infections and Clinical Outcomes, 10 US Sites, 2020-–2022. |
| Authors: |
Grass, Julian E, Bulens, Sandra N, Ansari, Uzma A, Duffy, Nadezhda, Jacob, Jesse T, Smith, Gillian, Rebolledo, Paulina A, Restrepo, Ana Mesa, Vaeth, Elisabeth, Dumyati, Ghinwa, Tsay, Rebecca, Looi, Hsioa Che, Phipps, Erin, Flores, Kristina G, Wilson, Christopher, Muleta, Daniel, Czaja, Christopher A, Driscoll, Jennifer, Johnston, Helen, Lynfield, Ruth |
| Source: |
Open Forum Infectious Diseases; Jan2025, Vol. 12 Issue 1, p1-7, 7p |
| Subject Terms: |
COVID-19, EMERGING infectious diseases, LOGISTIC regression analysis, COVID-19 pandemic, INTENSIVE care units |
| Abstract: |
Background We investigated hospitalized carbapenem-resistant Enterobacterales (CRE) and extended-spectrum β-lactamase–producing Enterobacterales (ESBL-E) cases with and without COVID-19, as identified through Emerging Infections Program surveillance in 10 sites from 2020 to 2022. Methods We defined a CRE case as the first isolation of Escherichia coli , Enterobacter cloacae complex, Klebsiella aerogenes , K oxytoca , K pneumoniae , or K variicola resistant to any carbapenem. We defined an ESBL-E case as the first isolation of E coli , K pneumoniae , or K oxytoca resistant to any third-generation cephalosporin and nonresistant to all carbapenems tested. Specimens were drawn from a normally sterile site or urine among hospitalized residents of the surveillance area in a 30-day period. We defined COVID-19 as a positive SARS-CoV-2 test result (SC2+) within 14 days before CRE or ESBL-E specimen collection and performed multivariable logistic regression analyses. Results Of 1595 CRE and 1866 ESBL-E hospitalized cases, 38 (2.4%) and 60 (3.2%), respectively, had a SC2+. Among these cases, a SC2+ was associated with intensive care unit admission (adjusted odds ratio [aOR], 1.69 [95% CI, 1.14–2.50]; aOR, 1.48 [95% CI, 1.03–2.12]) and 30-day mortality (aOR, 1.79 [95% CI, 1.22–2.64]; aOR, 1.94 [95% CI, 1.39–2.70]). Conclusions CRE and ESBL-E infections among hospitalized patients with preceding COVID-19 were uncommon but had worse outcomes when compared with cases without COVID-19. COVID-19 prevention in patients at risk of CRE and ESBL-E infections is needed, as well as continued infection control measures and antibiotic stewardship for patients with COVID-19. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
