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Microneedle-Mediated Treatment of Obesity.

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Title: Microneedle-Mediated Treatment of Obesity.
Authors: Pan, Huanhuan, Hu, Wanshan, Zhou, Chunxian, Jian, Jubo, Xu, Jing, Lu, Chao, Quan, Guilan, Wu, Chuanbin, Pan, Xin, Peng, Tingting
Source: Pharmaceutics; Feb2025, Vol. 17 Issue 2, p248, 23p
Subject Terms: WHITE adipose tissue, BROWN adipose tissue, TRANSDERMAL medication, DRUG delivery systems, DIABETES complications, MORBID obesity, ADIPOSE tissues
Abstract: Obesity has become a major public health threat, as it can cause various complications such as diabetes, cardiovascular disease, sleep apnea, cancer, and osteoarthritis. The primary anti-obesity therapies include dietary control, physical exercise, surgical interventions, and drug therapy; however, these treatments often have poor therapeutic efficacy, significant side effects, and unavoidable weight rebound. As a revolutionized transdermal drug delivery system, microneedles (MNs) have been increasingly used to deliver anti-obesity therapeutics to subcutaneous adipose tissue or targeted absorption sites, significantly enhancing anti-obese effects. Nevertheless, there is still a lack of a review to comprehensively summarize the latest progress of MN-mediated treatment of obesity. This review provides an overview of the application of MN technology in obesity, focusing on the delivery of various therapeutics to promote the browning of white adipose tissue (WAT), suppress adipogenesis, and improve metabolic function. In addition, this review presents detailed examples of the integration of MN technology with iontophoresis (INT) or photothermal therapy (PTT) to promote drug penetration into deeper dermis and exert synergistic anti-obese effects. Furthermore, the challenges and prospects of MN technology used for obesity treatment are also discussed, which helps to guide the design and optimization of MNs. Overall, this review provides insight into the development and clinical translation of MN technology for the treatment of obesity. [ABSTRACT FROM AUTHOR]
Copyright of Pharmaceutics is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Complementary Index
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  Label: Title
  Group: Ti
  Data: Microneedle-Mediated Treatment of Obesity.
– Name: Author
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  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Pan%2C+Huanhuan%22">Pan, Huanhuan</searchLink><br /><searchLink fieldCode="AR" term="%22Hu%2C+Wanshan%22">Hu, Wanshan</searchLink><br /><searchLink fieldCode="AR" term="%22Zhou%2C+Chunxian%22">Zhou, Chunxian</searchLink><br /><searchLink fieldCode="AR" term="%22Jian%2C+Jubo%22">Jian, Jubo</searchLink><br /><searchLink fieldCode="AR" term="%22Xu%2C+Jing%22">Xu, Jing</searchLink><br /><searchLink fieldCode="AR" term="%22Lu%2C+Chao%22">Lu, Chao</searchLink><br /><searchLink fieldCode="AR" term="%22Quan%2C+Guilan%22">Quan, Guilan</searchLink><br /><searchLink fieldCode="AR" term="%22Wu%2C+Chuanbin%22">Wu, Chuanbin</searchLink><br /><searchLink fieldCode="AR" term="%22Pan%2C+Xin%22">Pan, Xin</searchLink><br /><searchLink fieldCode="AR" term="%22Peng%2C+Tingting%22">Peng, Tingting</searchLink>
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  Data: Pharmaceutics; Feb2025, Vol. 17 Issue 2, p248, 23p
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22WHITE+adipose+tissue%22">WHITE adipose tissue</searchLink><br /><searchLink fieldCode="DE" term="%22BROWN+adipose+tissue%22">BROWN adipose tissue</searchLink><br /><searchLink fieldCode="DE" term="%22TRANSDERMAL+medication%22">TRANSDERMAL medication</searchLink><br /><searchLink fieldCode="DE" term="%22DRUG+delivery+systems%22">DRUG delivery systems</searchLink><br /><searchLink fieldCode="DE" term="%22DIABETES+complications%22">DIABETES complications</searchLink><br /><searchLink fieldCode="DE" term="%22MORBID+obesity%22">MORBID obesity</searchLink><br /><searchLink fieldCode="DE" term="%22ADIPOSE+tissues%22">ADIPOSE tissues</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Obesity has become a major public health threat, as it can cause various complications such as diabetes, cardiovascular disease, sleep apnea, cancer, and osteoarthritis. The primary anti-obesity therapies include dietary control, physical exercise, surgical interventions, and drug therapy; however, these treatments often have poor therapeutic efficacy, significant side effects, and unavoidable weight rebound. As a revolutionized transdermal drug delivery system, microneedles (MNs) have been increasingly used to deliver anti-obesity therapeutics to subcutaneous adipose tissue or targeted absorption sites, significantly enhancing anti-obese effects. Nevertheless, there is still a lack of a review to comprehensively summarize the latest progress of MN-mediated treatment of obesity. This review provides an overview of the application of MN technology in obesity, focusing on the delivery of various therapeutics to promote the browning of white adipose tissue (WAT), suppress adipogenesis, and improve metabolic function. In addition, this review presents detailed examples of the integration of MN technology with iontophoresis (INT) or photothermal therapy (PTT) to promote drug penetration into deeper dermis and exert synergistic anti-obese effects. Furthermore, the challenges and prospects of MN technology used for obesity treatment are also discussed, which helps to guide the design and optimization of MNs. Overall, this review provides insight into the development and clinical translation of MN technology for the treatment of obesity. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Pharmaceutics is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.3390/pharmaceutics17020248
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      – Code: eng
        Text: English
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        PageCount: 23
        StartPage: 248
    Subjects:
      – SubjectFull: WHITE adipose tissue
        Type: general
      – SubjectFull: BROWN adipose tissue
        Type: general
      – SubjectFull: TRANSDERMAL medication
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      – SubjectFull: DRUG delivery systems
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      – SubjectFull: DIABETES complications
        Type: general
      – SubjectFull: MORBID obesity
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      – SubjectFull: ADIPOSE tissues
        Type: general
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      – TitleFull: Microneedle-Mediated Treatment of Obesity.
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              M: 02
              Text: Feb2025
              Type: published
              Y: 2025
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