Bibliographic Details
| Title: |
Dodecafluoropentane improves neuro-behavioral outcomes and return of spontaneous circulation rate in a swine model of cardiac arrest. |
| Authors: |
Murphy, Travis W., Cueto, Robert J., Zhu, Jiepei, Milling, Jacob, Sauter, Justin, Oli, Muna, Griffin, Ian T., Midathala, Gagan, Tyndall, J. Adrian, Spiess, Bruce, Wang, Kevin K. W., Kobeissy, Firas H., Becker, Torben K. |
| Source: |
Brain Injury; 2025, Vol. 39 Issue 4, p277-285, 9p |
| Subject Terms: |
SWINE, NEUROLOGIC manifestations of general diseases, RESEARCH funding, STATISTICAL sampling, FUNCTIONAL assessment, TREATMENT effectiveness, ODDS ratio, ANIMAL experimentation, HISTOLOGICAL techniques, CARDIAC arrest, RETURN of spontaneous circulation, CARDIOPULMONARY resuscitation, SURVIVAL analysis (Biometry), FLUOROCARBONS, BIOMARKERS, DISEASE complications |
| Abstract: |
Introduction: Dodecafluoropentane emulsion (DDFPe) administration has previously demonstrated improved gas exchange in single-organ perfusion models. This could translate to prevention of brain injury in cardiac arrest. Methods: We induced cardiac arrest in 12 pigs, performing CPR after 5-minute downtime. Pigs were randomly assigned to DDFPe (n = 7) or saline placebo (n = 5) groups. Neurologic injury biomarkers were measured at baseline, after return of spontaneous circulation (ROSC), and every 24 hours in survivors. Blinded Neurological Alertness Score, Neurological Dysfunction Score, and Overall Performance Score was performed in addition to histopathological scoring of parietal and hippocampal sections. Results: One placebo and four DDFPe pigs survived the 96-hour observation period. The odds ratio for ROSC was 7.2 (p = 0.22). Survival odds ratio was 4.6 (p = 0.29). All surviving animals had impaired motor responses that recovered by 72 hours. DDFPe animals showed better neuro-behavioral scores than placebo. Conclusion: The findings of this novel study provide a proof of concept and early signal toward efficacy of intravenous DDFPe in cardiac arrest. The trend toward improved ROSC and functional survival may reflect improved microcirculatory gas exchange in DDFPe animals. Improving gas exchange in brain microcirculation during resuscitation from cardiac arrest may provide a significant therapeutic benefit. [ABSTRACT FROM AUTHOR] |
|
Copyright of Brain Injury is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
