Academic Journal
View in EDS

Coacervation drives morphological diversity of mRNA encapsulating nanoparticles.

Bibliographic Details
Title: Coacervation drives morphological diversity of mRNA encapsulating nanoparticles.
Authors: Pert, Emmit K., Hurst, Paul J., Waymouth, Robert M., Rotskoff, Grant M.
Source: Journal of Chemical Physics; 2/21/2025, Vol. 162 Issue 7, p1-19, 19p
Subject Terms: BLOCK copolymers, SPATIAL arrangement, PHASE diagrams, COACERVATION, NANOPARTICLES
Abstract: The spatial arrangement of components within an mRNA encapsulating nanoparticle has consequences for its thermal stability, which is a key parameter for therapeutic utility. The mesostructure of mRNA nanoparticles formed with cationic polymers has several distinct putative structures: here, we develop a field theoretic simulation model to compute the phase diagram for amphiphilic block copolymers that balance coacervation and hydrophobicity as driving forces for assembly. We predict several distinct morphologies for the mesostructure of these nanoparticles, depending on salt conditions and hydrophobicity. We compare our predictions with cryogenic-electron microscopy images of mRNA encapsulated by charge altering releasable transporters. In addition, we provide a graphics processing unit-accelerated, open-source codebase for general purpose field theoretic simulations, which we anticipate will be a useful tool for the community. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Chemical Physics is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Complementary Index
FullText Links:
  – Type: other
Text:
  Availability: 0
CustomLinks:
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edb&genre=article&issn=00219606&ISBN=&volume=162&issue=7&date=20250221&spage=1&pages=1-19&title=Journal of Chemical Physics&atitle=Coacervation%20drives%20morphological%20diversity%20of%20mRNA%20encapsulating%20nanoparticles.&aulast=Pert%2C%20Emmit%20K.&id=DOI:10.1063/5.0235799
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
Header DbId: edb
DbLabel: Complementary Index
An: 183213652
RelevancyScore: 1162
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 1162.12329101563
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Coacervation drives morphological diversity of mRNA encapsulating nanoparticles.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Pert%2C+Emmit+K%2E%22">Pert, Emmit K.</searchLink><br /><searchLink fieldCode="AR" term="%22Hurst%2C+Paul+J%2E%22">Hurst, Paul J.</searchLink><br /><searchLink fieldCode="AR" term="%22Waymouth%2C+Robert+M%2E%22">Waymouth, Robert M.</searchLink><br /><searchLink fieldCode="AR" term="%22Rotskoff%2C+Grant+M%2E%22">Rotskoff, Grant M.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: Journal of Chemical Physics; 2/21/2025, Vol. 162 Issue 7, p1-19, 19p
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22BLOCK+copolymers%22">BLOCK copolymers</searchLink><br /><searchLink fieldCode="DE" term="%22SPATIAL+arrangement%22">SPATIAL arrangement</searchLink><br /><searchLink fieldCode="DE" term="%22PHASE+diagrams%22">PHASE diagrams</searchLink><br /><searchLink fieldCode="DE" term="%22COACERVATION%22">COACERVATION</searchLink><br /><searchLink fieldCode="DE" term="%22NANOPARTICLES%22">NANOPARTICLES</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The spatial arrangement of components within an mRNA encapsulating nanoparticle has consequences for its thermal stability, which is a key parameter for therapeutic utility. The mesostructure of mRNA nanoparticles formed with cationic polymers has several distinct putative structures: here, we develop a field theoretic simulation model to compute the phase diagram for amphiphilic block copolymers that balance coacervation and hydrophobicity as driving forces for assembly. We predict several distinct morphologies for the mesostructure of these nanoparticles, depending on salt conditions and hydrophobicity. We compare our predictions with cryogenic-electron microscopy images of mRNA encapsulated by charge altering releasable transporters. In addition, we provide a graphics processing unit-accelerated, open-source codebase for general purpose field theoretic simulations, which we anticipate will be a useful tool for the community. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Chemical Physics is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edb&AN=183213652
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1063/5.0235799
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 19
        StartPage: 1
    Subjects:
      – SubjectFull: BLOCK copolymers
        Type: general
      – SubjectFull: SPATIAL arrangement
        Type: general
      – SubjectFull: PHASE diagrams
        Type: general
      – SubjectFull: COACERVATION
        Type: general
      – SubjectFull: NANOPARTICLES
        Type: general
    Titles:
      – TitleFull: Coacervation drives morphological diversity of mRNA encapsulating nanoparticles.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Pert, Emmit K.
      – PersonEntity:
          Name:
            NameFull: Hurst, Paul J.
      – PersonEntity:
          Name:
            NameFull: Waymouth, Robert M.
      – PersonEntity:
          Name:
            NameFull: Rotskoff, Grant M.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 21
              M: 02
              Text: 2/21/2025
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-print
              Value: 00219606
          Numbering:
            – Type: volume
              Value: 162
            – Type: issue
              Value: 7
          Titles:
            – TitleFull: Journal of Chemical Physics
              Type: main
ResultId 1