| Title: |
Divergent Crosstalk Between Microglia and T Cells in Brain Cancers: Implications for Novel Therapeutic Strategies. |
| Authors: |
Yi, Min-Hee, Lee, Jinkyung, Moon, Subin, So, EunA, Bang, Geonhyeok, Moon, Kyung-Sub, Lee, Kyung-Hwa |
| Source: |
Biomedicines; Jan2025, Vol. 13 Issue 1, p216, 19p |
| Subject Terms: |
SCIENTIFIC literature, CELL populations, T cells, CANCER invasiveness, BRAIN cancer |
| Abstract: |
Background: Brain cancers represent a formidable oncological challenge characterized by their aggressive nature and resistance to conventional therapeutic interventions. The tumor microenvironment has emerged as a critical determinant of tumor progression and treatment efficacy. Within this complex ecosystem, microglia and macrophages play fundamental roles, forming intricate networks with peripheral immune cell populations, particularly T cells. The precise mechanisms underlying microglial interactions with T cells and their contributions to immunosuppression remain incompletely understood. Methods: This review comprehensively examines the complex cellular dialogue between microglia and T cells in two prominent brain malignancies: primary glioblastoma and secondary brain metastases. Results: Through a comprehensive review of the current scientific literature, we explore the nuanced mechanisms through which microglial-T cell interactions modulate tumor growth and immune responses. Conclusions: Our analysis seeks to unravel the cellular communication pathways that potentially underpin tumor progression, with the ultimate goal of illuminating novel therapeutic strategies for brain cancer intervention. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
