| Title: |
Characteristics of HIV molecular transmission network of men who have sex with men among newly reported HIV cases, Jinan, 2022 -2023. (English) |
| Authors: |
HUANG Yu -jie, LIN Yu -xi, LI Xin, PAN Jing, HAN Xiu -yun, JIAO Hai -tao, LIU Lan - zheng |
| Source: |
Modern Preventive Medicine; 2024, Vol. 51 Issue 24, p4573-4579, 7p |
| Subject Terms: |
HIV infection transmission, HIV, MEN who have sex with men, MOLECULAR clusters, ANTI-HIV agents |
| Abstract: |
Objective To explore the characteristics of HIV molecular transmission network of men who have sex with men ( MSM) among newly reported HIV cases in Jinan, China. Methods The plasma samples of newly reported HIV - 1 MSM in Jinan from 2022 to 2023 were collected. The pol region gene was amplified using nested PCR followed by sequencing. The obtained sequences were used to construct phylogenetic tree and molecular transmission network. The related factors for participants entering a cluster were analyzed. Drug resistance mutations were identified and analyzed using the online software of HIV drug resistance database of Stanford University. Results This study obtained 207 sequences and identified 15 HIV - 1 subtypes. The dominant subtypes were CRF07_BC (76/207, 36. 7% ) and CRF01_AE (74/207, 35. 7% ), Mowed by B subtypes (21/207, 10. 1% ), CRF114_0155 (9/207, 4. 3% ), and CRF55_01B (8/207, 3. 9% ). Setting 1. 5% as the gene distance threshold, a total of 15 molecular clusters were formed by 42 sequences, with a transmission network entry rate of 20. 3%. Multivariate Logistic Analysis results showed that MSM with college or above education level and CD4 count >500 cells/µl were more likely to enter the molecular transmission network. Among the 207 participants, 11(5. 3% ) were detected with drug resistance mutations, including 2 with PI resistance mutations, 6 with NRTI resistance mutations, 2 with NNRTI resistance mutations, and 2 with INSTI resistance mutations. One participant was detected with both NRTI and NNRTI resistance mutations. Conclusion The gene subtypes of newly reported HIV cases are diverse, mainly were CRF07_BC and CRF01 _AE. MSM with younger age and higher education level are active populations in the HIV transmission network. HIV transmission network monitoring is a long - term and continuous work, and it is necessary to strengthen the traceability of key populations in the network and provide more effective intervention strategies to reduce the HIV transmission. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
