Bibliographic Details
| Title: |
Serum leptin and adiponectin function as indicators of allergic sensitization in pediatric adenotonsillar hypertrophy. |
| Authors: |
Li, Chaojie, Guo, Ruixiang, Liu, Yanyan, Zhang, Yijing, Yang, Yan, Ni, Shoujie, Sun, Xiaojing, Liu, Huayang, Zhao, Zehua, Li, Yanzhong, Zou, Juanjuan, Wang, Yan, Lei, Dapeng |
| Source: |
European Archives of Oto-Rhino-Laryngology; Jan2025, Vol. 282 Issue 1, p457-466, 10p |
| Subject Terms: |
IMMUNOGLOBULIN E, LEPTIN, ADIPOKINES, CHILDHOOD obesity, ADIPONECTIN |
| Abstract: |
Purpose: Obesity is commonly linked to both adenotonsillar hypertrophy (ATH) and allergic disorders, in which the roles of adipokines are not fully illuminated. This study aims to investigate the levels of leptin and adiponectin and their associations with allergic sensitization in pediatric ATH. Methods: Serum levels of specific immunoglobulin E (IgE), leptin and adiponectin were quantified in 35 controls and 111 ATH children, in which 54 were non-atopic and 57 were atopic. Spearman's correlation analysis and polynomial linear trend test were conducted. The odds ratios and 95% confidence intervals were calculated by binary logistic regression after multivariable adjustment. Results: The serum level of leptin and leptin/adiponectin (L/A) ratio was significantly increased in children with ATH. An increase in leptin level and L/A ratio and a decrease in adiponectin level were observed in atopic children compared with non-atopic children. Among ATH children, the level of adiponectin was negatively while L/A ratio was positively correlated with specific IgE. After multivariable adjustment, leptin was significantly associated with increased risk of atopy to D. pteronyssinus and D. farina, and adiponectin was significantly associated with decreased risk of atopy to willow and mugwort. Leptin was associated with higher odds while adiponectin was associated with lower odds of overall atopy. Besides, significant multiplicative interactions of obesity with leptin and adiponectin on atopy were observed respectively. Conclusion: Leptin and adiponectin were both associated with allergic sensitization and function differently in pediatric ATH. Mechanistic studies are needed to elucidate the involvement of adipokines in allergic sensitization of pediatric ATH. [ABSTRACT FROM AUTHOR] |
|
Copyright of European Archives of Oto-Rhino-Laryngology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
