| Title: |
Pan-cancer genomic analysis reveals FOXA1 amplification is associated with adverse outcomes in non–small cell lung, prostate, and breast cancers. |
| Authors: |
Goglia, Alexander G, Alshalalfa, Mohammed, Khan, Anwar, Isakov, Danielle R, Hougen, Helen Y, Swami, Nishwant, Kannikal, Jasmine, Mcbride, Sean M, Gomez, Daniel R, Punnen, Sanoj, Nguyen, Paul L, Iyengar, Puneeth, Antonarakis, Emmanuel S, Mahal, Brandon A, Dee, Edward Christopher |
| Source: |
JNCI: Journal of the National Cancer Institute; Jan2025, Vol. 117 Issue 1, p188-197, 10p |
| Subject Terms: |
SMALL cell lung cancer, NON-small-cell lung carcinoma, PROSTATE cancer prognosis, PROSTATE cancer, TRANSCRIPTION factors |
| Abstract: |
Background Alterations in forkhead box A1 (FOXA1), a pioneer transcription factor, are associated with poor prognosis in breast cancer and prostate cancer. We characterized FOXA1 genomic alterations and their clinical impacts in a large pan-cancer cohort from the American Association for Cancer Research Genomics, Evidence, Neoplasia, Information, Exchange database. Methods FOXA1 alterations were characterized across more than 87 000 samples from more than 30 cancer types for primary and metastatic tumors alongside patient characteristics and clinical outcomes. FOXA1 alterations were queried in the Memorial Sloan Kettering - Metastatic Events and Tropisms (MSK-MET) cohort (a GENIE subset), allowing definition of hazard ratios (HRs) and survival estimates based on Cox proportional hazard models. Results FOXA1 was altered in 1869 (2.1%) samples, with distinct patterns across different cancers: prostate cancer enriched with indel-inframe alterations, breast cancer with missense mutations, and lung cancers with copy number amplifications. Of 74 715 samples with FOXA1 copy number profiles, amplification was detected in 834 (1.1%). Amplification was most common in non–small cell lung cancer (NSCLC; 3% in primary; 6% in metastatic) and small cell lung cancer (4.1% primary; 3.5% metastatic), followed by breast cancer (2% primary; 1.6% metastatic) and prostate cancer (2.2% primary; 1.6% metastatic). Copy number amplifications were associated with decreased overall survival in NSCLC (HR = 1.45, 95% confidence interval [CI] = 1.06 to 1.99; P = .02), breast cancer (HR = 3.04, 95% CI = 1.89 to 4.89; P = 4e−6), and prostate cancer (HR = 1.94, 95% CI = 1.03 to 3.68; P = .04). Amplifications were associated with widespread metastases in NSCLC, breast cancer, and prostate cancer. Conclusions FOXA1 demonstrates distinct alteration profiles across cancer sites. Our findings suggest an association between FOXA1 amplification and enhanced metastatic potential and decreased survival, highlighting prognostic and therapeutic potential in breast cancer, prostate cancer, and NSCLC. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
