| Title: |
Montreal cognitive assessment as a cognitive outcome measure in progressive supranuclear palsy. |
| Authors: |
Ibrahim, Vanessa, Isroff, Catherine, Stephen, Christopher D., Iyer, Jay, Dale, Marian L., Gunzler, Douglas A., Bayram, Ece, Xie, Tao, Pantelyat, Alex, Montaser-Kouhsari, Leila, Garcia-Cordero, Indira, Tartaglia, Maria Carmela, Lang, Anthony E., Swan, Matthew, Boxer, Adam L., Golbe, Lawrence I., Wills, Anne-Marie |
| Source: |
Frontiers in Neurology; 2025, p1-6, 6p |
| Subject Terms: |
MONTREAL Cognitive Assessment, PROGRESSIVE supranuclear palsy, NEUROPSYCHOLOGICAL tests, COGNITION disorders, CLINICAL trials |
| Abstract: |
Background: The Montreal Cognitive assessment (MoCA) is a well-validated global cognitive screening instrument. Its validity in progressive supranuclear palsy (PSP) has not been assessed. Objectives: To evaluate the MoCA as an outcome measure in PSP clinical trials. Methods: Cognitive data from 162 participants in the placebo arm of the Biogen PASSPORT study (NCT03068468) were analyzed using linear mixed-effects modeling (LMM) and repeated measures correlation. Results: There was a significant decline in the MoCA score over time of −1.4 (95% CI −0.84 to −1.97) points over a 48-week period (p < 0.0001). Small but significant changes (p < 0.01) were observed in all MoCA domains except abstraction. The MoCA correlated weakly with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) over time (r rm = 0.1, p = 0.02) but exhibited a stronger correlation with the PSP Rating Scale (PSPRS) (r rm = −0.25, p < 0.0001). Conclusion: The MoCA appears to have limited sensitivity in capturing cognitive decline in PSP. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
