Bibliographic Details
| Title: |
Opportunities and challenges of bacterial extracellular vesicles in regenerative medicine. |
| Authors: |
Guo, Jiming, Huang, Zhijie, Wang, Qinjing, Wang, Min, Ming, Yue, Chen, Weixing, Huang, Yisheng, Tang, Zhengming, Huang, Mingshu, Liu, Hongyu, Jia, Bo |
| Source: |
Journal of Nanobiotechnology; 1/4/2025, Vol. 23 Issue 1, p1-27, 27p |
| Subject Terms: |
EXTRACELLULAR vesicles, BILAYER lipid membranes, GENOME editing, IMMUNE response, TREATMENT effectiveness, REGENERATIVE medicine, POLYMERSOMES |
| Abstract: |
Extracellular vesicles (EVs) are membrane-bound vesicles that are shed or secreted from the cell membrane and enveloped by a lipid bilayer. They possess stability, low immunogenicity, and non-cytotoxicity, exhibiting extensive prospects in regenerative medicine (RM). However, natural EVs pose challenges, such as insufficient targeting capabilities, potential biosafety concerns, and limited acquisition pathways. Although engineered EVs demonstrate excellent therapeutic efficacy, challenges such as low production yield and the complexity of engineering modifications constrain their further clinical applications. Bacteria have advantages such as rapid proliferation, diverse gene editing methods, mature cultivation techniques, and relatively easy preparation of bacterial EVs (BEVs), which can be used to effectively address the challenges currently encountered in the field of EVs. This review provides a description of the biogenesis and pathophysiological functions of BEVs, and strategies for optimizing BEVs preparation to attain efficiency and safety are discussed. An analysis of natural characteristics of BEVs is also conducted to explore how to leverage their advantages or mitigate their limitations, thereby overcoming constraints on the application of BEVs in RM. In summary, engineered BEVs possess characteristics such as high production yield, excellent stability, and high drug-delivering capabilities, laying the foundation for their application in RM. Highlights: Elucidated the advantages and limitations of naturally occurring bacterial extracellular vesicles for regenerative medicine. Provided an overview of the preparation, characterization, and engineering strategies of bacterial extracellular vesicles, and explored from these perspectives how to alleviate the application limitations of bacterial extracellular vesicles in regenerative medicine. Discussed the current challenges and potential applications of bacterial extracellular vesicles. Summarized the immense potential of engineered bacterial extracellular vesicles as innovative therapies in regenerative medicine, particularly from the perspectives of drug delivery, tissue regeneration, and antibacterial effects. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
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