Bibliographic Details
| Title: |
The association of arterial partial oxygen pressure with mortality in critically ill sepsis patients: a nationwide observational cohort study. |
| Authors: |
Hyun, Dong-gon, Ahn, Jee Hwan, Huh, Jin Won, Hong, Sang-Bum, Koh, Younsuck, Oh, Dong Kyu, Lee, Su Yeon, Park, Mi Hyeon, Lim, Chae-Man |
| Source: |
Critical Care; 12/18/2024, Vol. 28 Issue 1, p1-9, 9p |
| Abstract: |
Background: Although several trials were conducted to optimize the oxygenation range in intensive care unit (ICU) patients, no studies have yet reached a universal recommendation on the optimal a partial pressure of oxygen in arterial blood (PaO2) range in patients with sepsis. Our aim was to evaluate whether a relatively high arterial oxygen tension is associated with longer survival in sepsis patients compared with conservative arterial oxygen tension. Methods: From the Korean Sepsis Alliance nationwide registry, patients treated with liberal PaO2 (PaO2 ≥ 80 mm Hg) were 1:1 matched with those treated with conservative PaO2 (PaO2 < 80 mm Hg) over the first three days after ICU admission according to the propensity score. The primary outcome was 28-day mortality. Results: The median values of PaO2 over the first three ICU days in 1211 liberal and 1211 conservative PaO2 groups were, respectively, 107.2 (92.0–134.0) and 84.4 (71.2–112.0) in day 1110.0 (93.4–132.0) and 80.0 (71.0–100.0) in day 2, and 106.0 (91.9–127.4) and 78.0 (69.0–94.5) in day 3 (all p-values < 0.001). The liberal PaO2 group showed a lower likelihood of death at day 28 (14.9%; hazard ratio [HR], 0.79; 95% confidence interval [CI] 0.65–0.96; p-value = 0.017). ICU (HR, 0.80; 95% CI 0.67–0.96; p-value = 0.019) and hospital mortalities (HR, 0.84; 95% CI 0.73–0.97; p-value = 0.020) were lower in the liberal PaO2 group. On ICU days 2 (p-value = 0.007) and 3 (p-value < 0.001), but not ICU day 1, hyperoxia was associated with better prognosis compared with conservative oxygenation., with the lowest 28-day mortality, especially at PaO2 of around 100 mm Hg. Conclusions: In critically ill patients with sepsis, higher PaO2 (≥ 80 mm Hg) during the first three ICU days was associated with a lower 28-day mortality compared with conservative PaO2. [ABSTRACT FROM AUTHOR] |
|
Copyright of Critical Care is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
