Bibliographic Details
| Title: |
Insulin autoimmune syndrome without hypoglycemia: A different perspective of method interference. (English) |
| Authors: |
Yesildal, Fatih, Kado, Ahmad, Isman, Ferruh Kemal |
| Source: |
Northern Clinics of Istanbul; 2024, Vol. 11 Issue 6, p575-578, 4p |
| Subject Terms: |
GEL permeation chromatography, INSULIN antibodies, POLYETHYLENE glycol, AUTOIMMUNE diseases, HYPOGLYCEMIA |
| Abstract: |
Insulin autoimmune syndrome (IAS) is a serious autoimmune disorder that may cause spontaneous hypoglycemia. IAS is characterized by hyperinsulinemia, normal C-peptide levels and positive anti-insulin antibody. The diagnosis is confirmed by demonstrating the presence of macroinsulin complex by polyethylene glycol (PEG) precipitation or gel filtration chromatography. Although some macrohormones like macroprolactin and some macroenzymes such as macroamylase are seen commonly, macroinsulinemia is a rare condition. In this report, we presented an IAS case from laboratory perspective by using three different immunoassays with different performances in eliminating macroinsulin interference. Besides presenting a case with IAS without hypoglycemia we evaluated the contribution of different immunoassays to the diagnosis of this syndrome. Immunoassays have different features, considering the analysis of macroinsulin or bioavailable insulin. In this case, the superiority or handicap of these immunoassays will be discussed in terms of analysis of total or free insulin. [ABSTRACT FROM AUTHOR] |
|
Copyright of Northern Clinics of Istanbul is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
