Bibliographic Details
| Title: |
Validation of the second revision of the international staging system (R2-ISS) for overall survival in multiple myeloma in a real-world cohort: an analysis by the Balkan myeloma study group (BMSG). |
| Authors: |
Kastritis, Efstathios, Katodritou, Eirini, Badelita, Sorina, Bila, Jelena, Seval, Güldane Cengiz, Cvetkovic, Zorica, Coriu, Daniel, Spanoudakis, Emmanouil, Dalampira, Dimitra, Sretenovic, Aleksandra, Sevastoudi, Aggeliki, Bojan, Anca, Mitrovic, Marko, Danaila, Catalin, Gavriatopoulou, Maria, Roussou, Maria, Charalampous, Charalampos, Terpos, Evangelos, Beksac, Meral, Dimopoulos, Meletios A. |
| Source: |
Leukemia & Lymphoma; Dec2024, Vol. 65 Issue 13, p2064-2067, 4p |
| Subject Terms: |
PROPORTIONAL hazards models, STEM cell transplantation, LACTATE dehydrogenase, PROGNOSTIC tests, PROGNOSTIC models |
| Abstract: |
The document discusses the validation of the Revised-2 International Staging System (R2-ISS) for overall survival in multiple myeloma patients within the Balkan Myeloma Study Group (BMSG). The R2-ISS incorporates serum LDH, del17p, t(4;14), and +1q21 aberrations to classify patients into four risk categories. The study compared R-ISS and R2-ISS in a real-world cohort of 1,503 patients, showing significant differences in overall survival across stages II and III and stages III and IV. The R2-ISS was found to better identify high-risk patients, especially within the intermediate-risk group, suggesting its potential for tailoring treatment strategies and prioritizing patients for clinical trials. [Extracted from the article] |
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| Database: |
Complementary Index |
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