Bibliographic Details
| Title: |
Epicatechin as a promising agent against arsenic-induced neurobehavioral toxicity in NMRI mice: behavioral and biochemical alterations. |
| Authors: |
Shariati, Saeedeh, Khodayar, Mohammad Javad, Azadnasab, Reza, Nooshabadi, Mohammadreza Rashidi, Nikravesh, Mehrad, Khorsandi, Layasadat, Shirani, Kobra, Shirani, Maryam |
| Source: |
Naunyn-Schmiedeberg's Archives of Pharmacology; Dec2024, Vol. 397 Issue 12, p10143-10153, 11p |
| Subject Terms: |
NF-kappa B, OXIDANT status, ENCEPHALITIS, BEHAVIORAL assessment, OXIDATIVE stress, EPICATECHIN |
| Abstract: |
Epicatechin (Epi) is one of the most abundant flavonoids present in different fruits and tea leaves. Emerging research illuminates the promising potential of catechins to serve as a shield against the damaging effects of arsenic (As) exposure in diverse organs. This study sought to discern whether Epi exhibits a therapeutic efficacy against arsenic-induced neurotoxicity in a murine model. The Naval Medical Research Institute (NMRI) mice were randomly partitioned into six distinct groups, which included a control group receiving normal saline, a group receiving a daily oral dose of arsenic (10 mg/kg) for 5 weeks, groups receiving As (10 mg/kg/day) orally for 5 weeks along with different doses of Epi (25–100 mg/kg) orally for the last 2 weeks, and a group receiving Epi (100 mg/kg) orally for 2 weeks. To assess the potential effects of Epi, neurobehavioral tests, various parameters of oxidative stress, and inflammation were evaluated. The findings of this investigation revealed that As-induced neurobehavioral toxicity was associated with a notable surge in lipid peroxidation and nitric oxide (NO) concentration, accompanied by a reduction in the levels of antioxidant markers. As heightened pro-inflammatory cytokines including tumor necrosis factor-α (TNF-α) levels were observed alongside amplified nuclear factor kappa B (NF-κB) and nuclear factor erythroid 2–related factor 2 (Nrf2) expression. However, treatment with Epi reversed these effects. On the whole, these findings indicate that Epi may hold promise therapeutic efficacy on As-induced neurotoxicity by improving antioxidant status and mitigating oxidative stress and inflammation. Nevertheless, further research is imperative to comprehensively grasp the potential protective effects of Epi in this particular context. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
