Bibliographic Details
| Title: |
Treatment approaches to horses with acute diarrhea admitted to referral institutions: A multicenter retrospective study. |
| Authors: |
Gomez, Diego E., Kopper, Jamie J., Byrne, David P., Renaud, David L., Schoster, Angelika, Dunkel, Bettina, Arroyo, Luis G., Mykkanen, Anna, Gilsenan, William F., Pihl, Tina H., Lopez-Navarro, Gabriela, Tennent-Brown, Brett S., Hostnik, Laura D., Mora-Pereira, Mariano, Marques, Fernando, Gold, Jenifer R., DeNotta, Sally L., Desjardins, Isabelle, Stewart, Allison J., Kuroda, Taisuke |
| Source: |
PLoS ONE; 11/20/2024, Vol. 19 Issue 11, p1-19, 19p |
| Subject Terms: |
SYSTEMIC inflammatory response syndrome, POLYMYXIN B, ANTI-infective agents, THERAPEUTICS, FLUID therapy |
| Abstract: |
Background: This study aimed to describe and compare therapeutic approaches for horses with acute diarrhea in different geographic regions worldwide. Methods: Clinical information was retrospectively collected from diarrheic horses presented to participating institutions between 2016 and 2020, including fluid therapy on admission, antimicrobial drugs, probiotics, anti-endotoxic medications, anti-inflammatory drugs, gastroprotectants, digital cryotherapy, and toxin-binding agents. Seasonal and geographic differences were investigated. Results: 1438 horses from 26 participating hospitals from 5 continents were included. On admission, 65% (926/1419) of horses were administered a fluid bolus. Antimicrobial drugs were administered to 55% (792/1419) within the first 24 hours of admission, with penicillin and gentamicin being the most used combination (25%, 198/792). Horses with leukopenia (OR: 2.264, 95%CI: 1.754 to 2.921; P<0.001) or meeting systemic inflammatory response syndrome criteria (OR: 2.542, 95%CI: 1.919 to 3.368; P<0.001) had higher odds of being administered antimicrobial drugs. Other treatments administered included probiotics (15%, 215/1438), polymyxin B (13%; 187/1438), pentoxifylline (8%; 118/1438), gastroprotectants (44%; 626/1419), digital cryotherapy (34%; 489/1435), plasma transfusion (13%; 182/1410) and toxin-binding agents (36%; 515/1438). Limitations: Due to the retrospective nature of the study, the rationale for treatment decisions was unavailable, and associations with survival could not be evaluated. Conclusions: Treatments varied between hospitals from different geographic regions. Prospective clinical trials are required to evaluate the effects of various treatments on survival. [ABSTRACT FROM AUTHOR] |
|
Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
|
Full text is not displayed to guests. |
Login for full access.
|
