Bibliographic Details
| Title: |
Dietary pattern and the corresponding gut microbiome in response to immunotherapy in Thai patients with advanced non-small cell lung cancer (NSCLC). |
| Authors: |
Sitthideatphaiboon, Piyada, Somlaw, Nicha, Zungsontiporn, Nicha, Ouwongprayoon, Pongsakorn, Sukswai, Narittee, Korphaisarn, Krittiya, Poungvarin, Naravat, Aporntewan, Chatchawit, Hirankarn, Nattiya, Vinayanuwattikun, Chanida, Chanida, Vinayanuwattikun |
| Source: |
Scientific Reports; 11/14/2024, Vol. 12 Issue 1, p1-12, 12p |
| Subject Terms: |
DIETARY patterns, NON-small-cell lung carcinoma, IMMUNE checkpoint inhibitors, THAI people, GUT microbiome, FAT |
| Abstract: |
Gut microbiota is considered a key player modulating the response to immune checkpoint inhibitors (ICI) in cancer. The effects of dietary pattern on this interaction is not well-studied. A prospective multicenter cohort of 95 patients with advanced non-small cell lung cancer (NSCLC) undergoing ICI therapy were enrolled. Stool shotgun metagenomic sequencing was performed. Three-day dietary patterns before ICI were assessed. Patients were categorized as hyperprogressive disease (HPD) if they exhibited a time to treatment failure of less than 2 months. All others were categorized as non-hyperprogressive disease (non-HPD). The correlation between dietary patterns, gut microbiome, and response to ICI therapy was analyzed. In the multivariate analysis, a high abundance of Firmicutes unclassified and the Ruminococcaceae family correlated with a significantly diminished progression-free survival (PFS) with an HR of 2.40 [P = 0.006] and 4.30 [P = 0.005], respectively. More specifically, within the subset of NSCLC patients treated solely with ICI therapy, a high abundance of Intestinimonas and the Enterobacteriaceae family were associated with substantially reduced PFS with an HR of 2.61 [P = 0.02] and HR 3.34 [P = 0.005], respectively. In our comprehensive dietary pattern analysis, the HPD group showed increased consumption of cholesterol, sodium, and fats beyond recommended levels compared to the non-HPD group. This group also displayed a tendency towards higher food pattern scores characterized by a high intake of fat and dairy products. Our study revealed a distinct association between the gut microbiome composition and treatment outcomes. The overall composition of diet might be related to ICI therapeutic outcomes. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
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