Bibliographic Details
| Title: |
Muscarinic receptor drug trihexyphenidyl can alter growth of mesenchymal glioblastoma in vivo. |
| Authors: |
Du, Renfei, Sanin, Ahmed Y., Shi, Wenjie, Huang, Bing, Nickel, Ann-Christin, Vargas-Toscano, Andres, Huo, Shuran, Nickl-Jockschat, Thomas, Dumitru, Claudia A., Hu, Wei, Duan, Siyu, Sandalcioglu, I. Erol, Croner, Roland S., Alcaniz, Joshua, Walther, Wolfgang, Berndt, Carsten, Kahlert, Ulf D. |
| Source: |
Frontiers in Pharmacology; 2024, p1-12, 12p |
| Subject Terms: |
BRAIN tumors, DRUG receptors, DRUG repositioning, TUMOR classification, GLIOBLASTOMA multiforme, MUSCARINIC receptors |
| Abstract: |
Glioblastoma (GBM) is the most commonly occurring and most aggressive primary brain tumor. Transcriptomics-based tumor subtype classification has established the mesenchymal lineage of GBM (MES-GBM) as cancers with particular aggressive behavior and high levels of therapy resistance. Previously it was show that Trihexyphenidyl (THP), a market approved M1 muscarinic receptor-targeting oral drug can suppress proliferation and survival of GBM stem cells from the classical transcriptomic subtype. In a series of in vitro experiments, this study confirms the therapeutic potential of THP, by effectively suppressing the growth, proliferation and survival of MES-GBM cells with limited effects on non-tumor cells. Transcriptomic profiling of treated cancer cells identified genes and associated metabolic signaling pathways as possible underlying molecular mechanisms responsible for THP-induced effects. In vivo trials of THP in immunocompromised mice carry orthotopic MES-GBMs showed moderate response to the drug. This study further highlights the potential of THP repurposing as an anti-cancer treatment regimen but mode of action and d optimal treatment procedures for in vivo regimens need to be investigated further. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
