| Title: |
MYC translocation is a valuable marker for the development and relapse of extramedullary disease in multiple myeloma. |
| Authors: |
Song, Yuhang, Du, Jianhua, Jin, Xianghong, Li, Hui, Jia, Congwei, Liu, Yuanyuan, Li, Kaimi, Zhou, Daobin, Zhuang, Junling |
| Source: |
European Journal of Haematology; Dec2024, Vol. 113 Issue 6, p824-832, 9p |
| Subject Terms: |
FLUORESCENCE in situ hybridization, EXTRAMEDULLARY diseases, OVERALL survival, DISEASE relapse, MULTIPLE myeloma |
| Abstract: |
Objective: To study the cytogenetic characteristics of extramedullary disease (EMD) in patients with multiple myeloma (MM) and their impact on prognosis. Methods: Patients with newly diagnosed MM (NDMM) at Peking Union Medical College Hospital (Beijing, China) between June 2007 and December 2019 were recruited for this study. Demographic information, clinical data, fluorescence in situ hybridization (FISH) results of marrow and tissue samples, and survival outcome data were collected. Results: A total of 439 patients with NDMM were divided into those without EMD (non‐EMD, n = 339), those with EMD with primary paraosseous plasmacytoma (pEMD‐B, n = 48), those with primary EMD with soft‐tissue involvement (pEMD‐S, n = 33), and those with secondary EMD (sEMD, n = 19). The incidence of EMD was 18.5% (81/439) at diagnosis and 22.8% (100/439) throughout the disease course. Comparison of FISH results showed a higher proportion of RB1 deletion (n = 20; 60.0% vs. 20.0%, p =.013) and MYC translocation (n = 12; 44.4% vs. 12.5%, p =.041) in the extramedullary tissues than in the paired bone marrow samples. At diagnosis, the percentage of MYC translocations in the sEMD group was notably higher than that in the non‐EMD group (55.6% vs. 15.5%, p =.012). The median overall survival (OS) of patients with pEMD‐S (32 months) and sEMD (17 months) was significantly shorter (both p =.001) than that of non‐EMD patients (60 months). Conclusion: Soft‐tissue EMD can be considered a high‐risk condition, even in the era of novel agents. MYC translocation can serve as a valuable marker that correlates with extramedullary spread and relapse in patients with MM and should be considered for inclusion in routine FISH panels in clinical practice. [ABSTRACT FROM AUTHOR] |
|
Copyright of European Journal of Haematology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
