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Advances in Gouty Arthritis Management: Integration of Established Therapies, Emerging Treatments, and Lifestyle Interventions.

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Title: Advances in Gouty Arthritis Management: Integration of Established Therapies, Emerging Treatments, and Lifestyle Interventions.
Authors: Yao, Ting-Kuo, Lee, Ru-Ping, Wu, Wen-Tien, Chen, Ing-Ho, Yu, Tzai-Chiu, Yeh, Kuang-Ting
Source: International Journal of Molecular Sciences; Oct2024, Vol. 25 Issue 19, p10853, 19p
Subject Terms: WATERMELONS, THERAPEUTICS, DRUG additives, OZONE therapy, ANTI-inflammatory agents
Abstract: Gouty arthritis, a prevalent inflammatory condition characterized by the deposition of monosodium urate crystals within joints, often results in debilitating pain and inflammation. Conventional therapeutic approaches, including nonsteroidal anti-inflammatory drugs, corticosteroids, and urate-lowering agents such as allopurinol and febuxostat, often have limitations such as adverse effects, drug interactions, and suboptimal patient compliance. This review presents a comprehensive overview of both established and emerging therapeutic strategies, developed between 2019 and 2024, for gouty arthritis; the review focuses on their mechanisms of action, efficacy, and safety profiles. Novel therapeutic approaches include pharmaceutical plant additives (e.g., Citrullus colocynthis, Atractylodes lancea), anti-inflammatory agents such as canakinumab and ozone therapy, and complementary therapies such as warm ginger compresses, Qingpeng ointment, and various lifestyle modifications. These strategies offer promising alternatives to conventional treatments by targeting uric acid metabolism, inflammatory pathways, and crystal formation, potentially reducing reliance on standard medications and minimizing adverse effects. Although therapies such as canakinumab have demonstrated significant efficacy in reducing gout flares, others such as polyphenol-rich foods offer favorable safety profiles. Further research, including large-scale clinical trials, is warranted to validate these findings and integrate these strategies into clinical practice to improve patient outcomes and quality of life. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Molecular Sciences is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Complementary Index
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  Data: Advances in Gouty Arthritis Management: Integration of Established Therapies, Emerging Treatments, and Lifestyle Interventions.
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  Data: <searchLink fieldCode="AR" term="%22Yao%2C+Ting-Kuo%22">Yao, Ting-Kuo</searchLink><br /><searchLink fieldCode="AR" term="%22Lee%2C+Ru-Ping%22">Lee, Ru-Ping</searchLink><br /><searchLink fieldCode="AR" term="%22Wu%2C+Wen-Tien%22">Wu, Wen-Tien</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+Ing-Ho%22">Chen, Ing-Ho</searchLink><br /><searchLink fieldCode="AR" term="%22Yu%2C+Tzai-Chiu%22">Yu, Tzai-Chiu</searchLink><br /><searchLink fieldCode="AR" term="%22Yeh%2C+Kuang-Ting%22">Yeh, Kuang-Ting</searchLink>
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  Data: International Journal of Molecular Sciences; Oct2024, Vol. 25 Issue 19, p10853, 19p
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  Data: <searchLink fieldCode="DE" term="%22WATERMELONS%22">WATERMELONS</searchLink><br /><searchLink fieldCode="DE" term="%22THERAPEUTICS%22">THERAPEUTICS</searchLink><br /><searchLink fieldCode="DE" term="%22DRUG+additives%22">DRUG additives</searchLink><br /><searchLink fieldCode="DE" term="%22OZONE+therapy%22">OZONE therapy</searchLink><br /><searchLink fieldCode="DE" term="%22ANTI-inflammatory+agents%22">ANTI-inflammatory agents</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Gouty arthritis, a prevalent inflammatory condition characterized by the deposition of monosodium urate crystals within joints, often results in debilitating pain and inflammation. Conventional therapeutic approaches, including nonsteroidal anti-inflammatory drugs, corticosteroids, and urate-lowering agents such as allopurinol and febuxostat, often have limitations such as adverse effects, drug interactions, and suboptimal patient compliance. This review presents a comprehensive overview of both established and emerging therapeutic strategies, developed between 2019 and 2024, for gouty arthritis; the review focuses on their mechanisms of action, efficacy, and safety profiles. Novel therapeutic approaches include pharmaceutical plant additives (e.g., Citrullus colocynthis, Atractylodes lancea), anti-inflammatory agents such as canakinumab and ozone therapy, and complementary therapies such as warm ginger compresses, Qingpeng ointment, and various lifestyle modifications. These strategies offer promising alternatives to conventional treatments by targeting uric acid metabolism, inflammatory pathways, and crystal formation, potentially reducing reliance on standard medications and minimizing adverse effects. Although therapies such as canakinumab have demonstrated significant efficacy in reducing gout flares, others such as polyphenol-rich foods offer favorable safety profiles. Further research, including large-scale clinical trials, is warranted to validate these findings and integrate these strategies into clinical practice to improve patient outcomes and quality of life. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Molecular Sciences is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Text: English
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              M: 10
              Text: Oct2024
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              Y: 2024
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