Bibliographic Details
| Title: |
Sex Differences in the Blood Metabolome During Acute Response to Ischemic Stroke. |
| Authors: |
Dylla, Layne, Higgins, Hannah M., Stephenson, Daniel, Reisz, Julie A., Vu, Thao, Poisson, Sharon N., Herson, Paco S., Monte, Andrew A. |
| Source: |
Journal of Women's Health (15409996); Oct2024, Vol. 33 Issue 10, p1378-1384, 7p |
| Subject Terms: |
STROKE units, NIH Stroke Scale, PROLINE, RESEARCH funding, SEX distribution, BLOOD collection, DESCRIPTIVE statistics, AGE distribution, POSTMENOPAUSE, CARDIOVASCULAR diseases risk factors, RETROSPECTIVE studies, HOSPITALS, METABOLITES, RACE, NUCLEOTIDES, CHOLINE, ESTERASES, LONGITUDINAL method, ISCHEMIC stroke, MASS spectrometry, AMINO acids, SEX (Biology), METABOLOMICS, TRYPTOPHAN, CITRATES, REGRESSION analysis, MENTAL depression, TIME |
| Geographic Terms: |
COLORADO |
| Abstract: |
Introduction: Females suffer greater lifetime risk of stroke and greater morbidity and mortality from stroke compared with males. This study's objective was to identify differences in metabolomic profiling of females and males with stroke and which differences were associated with neurological outcome. Methods: Females and males with acute ischemic stroke enrolled in the Emergency Medicine Specimen Bank at a comprehensive stroke center provided whole blood samples upon arrival for mass spectrometry-based metabolomics. We used descriptive statistics to characterize the cohort. A linear regression model was fit for individual metabolites to determine differences in relative abundance between males and females while controlling for covariates (age, race/ethnicity, postmenopausal status, cardiovascular risk factors, depression, time between sample collection and last known well, and initial National Institutes of Health Stroke Scale [NIHSS] score). For each differentially expressed metabolite, a linear regression model was fit to determine the association between the metabolite and NIHSS at 24 hours after admission while controlling for the covariates and acute treatments. Results: After adjusting for covariates, eight metabolites differed in females and males with a stroke. These included amino acids or their metabolites (proline and tryptophan), nucleotides (guanosine diphosphate [GDP], and inosine-3′,5′-cyclic monophosphate), citrate, dehydroascorbate, choline, and acylcarnitine-(5-OH). GDP and dehydroascorbate were significantly associated with 24-hour NIHSS (p = 0.0991). Conclusions: Few metabolites were differentially abundant in blood after a stroke when comparing females with males and controlling for confounders, but the interactions between biological sex and GDP, as well as biological sex and dehydroascorbate, were associated with 24-hour neurological function. This has important implications for future studies that evaluate the therapeutic potential of these metabolites in ischemic stroke. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
