Bibliographic Details
| Title: |
The Interactions of T Cells with Myeloid-Derived Suppressor Cells in Peripheral Blood Stem Cell Grafts. |
| Authors: |
Guan, Qingdong, Gilpin, Scott G., Doerksen, James, Bath, Lauren, Lam, Tracy, Li, Yun, Lambert, Pascal, Wall, Donna A. |
| Source: |
Cells (2073-4409); Sep2024, Vol. 13 Issue 18, p1545, 17p |
| Subject Terms: |
REGULATORY T cells, MYELOID-derived suppressor cells, HEMATOPOIETIC stem cell transplantation, T-cell exhaustion, BLOOD cells, T cells |
| Abstract: |
The interaction of myeloid-derived suppressor cells (MDSCs) with T cells within G-CSF-mobilized peripheral blood stem cell (PBSC) grafts in patients undergoing autologous or allogeneic hematopoietic stem cell transplantation remains to be elucidated. Through studying allo- and auto-PBSC grafts, we observed grafts containing large numbers of T cells and MDSCs with intergraft variability in their percentage and number. T cells from autologous grafts compared to allografts expressed relative higher percentages of inhibitory receptors PD-1, CTLA-4, TIM-3, LAG-3, TIGIT and BTLA. Autograft T cells had decreased cell proliferation and IFN-γ secretion, which supported the possible presence of T cell exhaustion. On the contrary, graft monocytic MDSCs (M-MDSCs) expressed multiple inhibitory receptor ligands, including PD-L1, CD86, Galectin-9, HVEM and CD155. The expression of inhibitory receptor ligands on M-MDSCs was correlated with their corresponding inhibitory receptors on T cells in the grafts. Isolated M-MDSCs had the ability to suppress T cell proliferation and IFN-γ secretion and/or promote Treg expansion. Blocking the PD-L1-PD-1 signaling pathway partially reversed the functions of M-MDSCs. Taken together, our data indicated that T cells and M-MDSCs in PBSC grafts express complementary inhibitory receptor–ligand pairing, which may impact the quality of immune recovery and clinical outcome post transplantation. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
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