| Title: |
Sacituzumab govitecan for hormone receptor–positive HER2-negative advanced breast cancer. |
| Authors: |
Garrigos, Laia, Camacho, Daniela, Perez-Garcia, José Manuel, Llombart-Cussac, Antonio, Cortes, Javier, Antonarelli, Gabriele |
| Source: |
Expert Review of Anticancer Therapy; Oct2024, Vol. 24 Issue 10, p949-958, 10p |
| Subject Terms: |
EPIDERMAL growth factor receptors, METASTATIC breast cancer, CYCLIN-dependent kinase inhibitors, HORMONE therapy, BREAST cancer |
| Abstract: |
Introduction: Initial treatment for hormone-receptor positive (HR+)/human epidermal growth factor receptor 2 negative (HER2-) advanced breast cancer (ABC) typically involves endocrine therapy (ET) combined with different targeted agents. When hormonal therapies fail, until recently, the only option available was chemotherapy (ChT), presenting a significant therapeutic challenge. However, the recent introduction of antibody–drug conjugates (ADCs) has provided new treatment alternatives in this context. Sacituzumab govitecan (SG), a novel trophoblast cell-surface antigen 2 (Trop-2)-targeting ADC, has been evaluated following disease progression to ET and ChT in HR+/HER2- ABC. Areas covered: This review examines the latest clinical trials, including phase I/II and III studies and evaluates the impact of SG on HR+/HER2- ABC. The literature search focused on clinical outcomes, particularly regarding efficacy and safety, comparing them with traditional ChT. Expert opinion: SG has demonstrated to be an effective treatment for patients with HR+/HER2- ABC after progression to ET and cyclin-dependent kinase 4/6 inhibitors (CDKi) in any setting, and at least two ChT-containing regimens in the advanced setting. With a manageable toxicity profile, SG represents a significant advancement in the treatment landscape for this patient population. However, further research is essential to optimize its application and establish long-term benefits. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
