Academic Journal
View in EDS

Stromal Cells Associated with Soft Tissue Augmentation by a Volume-Stable Collagen Matrix (VCMX) Are Predominated by Anti-inflammatory/Reparative Macrophages.

Bibliographic Details
Title: Stromal Cells Associated with Soft Tissue Augmentation by a Volume-Stable Collagen Matrix (VCMX) Are Predominated by Anti-inflammatory/Reparative Macrophages.
Authors: Artzi, Zvi, Vered, Marilena, Maymon-Gil, Tal, Renert, Uri, Netanely, Erez, Thoma, Daniel S.
Source: International Journal of Periodontics & Restorative Dentistry; Sep/Oct2024, Vol. 44 Issue 5, p601-611, 11p
Subject Terms: IMMUNOPHENOTYPING, MACROPHAGES, TISSUE engineering, ORAL mucosa, LYMPHOCYTES, MANN Whitney U Test, DESCRIPTIVE statistics, BIOMEDICAL materials, FIBROBLASTS, IMMUNOHISTOCHEMISTRY, ANTIGENS, STROMAL cells, ENDOTHELIAL cells, COLLAGEN, DATA analysis software, CONNECTIVE tissues, PHENOTYPES
Abstract: This article defines immunophenotypes of stromal inflammatory and endothelial cells and fibroblasts 3 months after augmentation of the peri-implant soft tissue using a porcine cross-linked collagen matrix (VCMX). Peri-implant soft tissue samples were obtained from 12 patients at the lining mucosa (LM)-masticatory mucosa (MM) junction before (1) and 3 months after (2) augmentation. Immu-nohistochemical stains were performed to identify inflammatory cells (T [CD3] and B [CD20] lymphocytes, plasma cells [CD138]), macrophages (CD68-proinflammatory, CD163-anti-inflammatory/ reparative), endothelial cells (CD31, CD34), and fibroblasts (CD90, TE-7). Differences in the mean positively stained cells pre- and postaugmentation were analyzed by Wilcoxon signed-rank test. CD31+ endothelial cells showed increased mean numbers in MM2 compared to MM1 (P = .025) and in LM2 compared to LM1 (P = .047). CD163+ anti-inflammatory macrophages showed higher mean numbers in MM2 than in MM1 (P = .021) and in LM2 than in LM1 (P = .012). All other cell phenotypes showed nonsignificant changes between pre- and postaugmentation. This molecular study provides novel insight on the frequency of stromal cell phenotypes in the wound healing process at 3 months postaugmentation with VCMX, with anti-inflammatory CD163+ macrophages being predominant. This should be further investigated to help find novel therapeutic approaches to modulate and promote the VCMX-related healing process. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Periodontics & Restorative Dentistry is the property of Quintessence Publishing Company Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Complementary Index
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://resolver.ebsco.com/c/xy5jbn/result?sid=EBSCO:edb&genre=article&issn=01987569&ISBN=&volume=44&issue=5&date=20240901&spage=601&pages=601-611&title=International Journal of Periodontics & Restorative Dentistry&atitle=Stromal%20Cells%20Associated%20with%20Soft%20Tissue%20Augmentation%20by%20a%20Volume-Stable%20Collagen%20Matrix%20%28VCMX%29%20Are%20Predominated%20by%20Anti-inflammatory%2FReparative%20Macrophages.&aulast=Artzi%2C%20Zvi&id=DOI:10.11607/prd.6819
    Name: Full Text Finder (for New FTF UI) (s8985755)
    Category: fullText
    Text: Find It @ SCU Libraries
    MouseOverText: Find It @ SCU Libraries
Header DbId: edb
DbLabel: Complementary Index
An: 179671939
RelevancyScore: 1121
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 1120.51928710938
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Stromal Cells Associated with Soft Tissue Augmentation by a Volume-Stable Collagen Matrix (VCMX) Are Predominated by Anti-inflammatory/Reparative Macrophages.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Artzi%2C+Zvi%22">Artzi, Zvi</searchLink><br /><searchLink fieldCode="AR" term="%22Vered%2C+Marilena%22">Vered, Marilena</searchLink><br /><searchLink fieldCode="AR" term="%22Maymon-Gil%2C+Tal%22">Maymon-Gil, Tal</searchLink><br /><searchLink fieldCode="AR" term="%22Renert%2C+Uri%22">Renert, Uri</searchLink><br /><searchLink fieldCode="AR" term="%22Netanely%2C+Erez%22">Netanely, Erez</searchLink><br /><searchLink fieldCode="AR" term="%22Thoma%2C+Daniel+S%2E%22">Thoma, Daniel S.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: International Journal of Periodontics & Restorative Dentistry; Sep/Oct2024, Vol. 44 Issue 5, p601-611, 11p
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22IMMUNOPHENOTYPING%22">IMMUNOPHENOTYPING</searchLink><br /><searchLink fieldCode="DE" term="%22MACROPHAGES%22">MACROPHAGES</searchLink><br /><searchLink fieldCode="DE" term="%22TISSUE+engineering%22">TISSUE engineering</searchLink><br /><searchLink fieldCode="DE" term="%22ORAL+mucosa%22">ORAL mucosa</searchLink><br /><searchLink fieldCode="DE" term="%22LYMPHOCYTES%22">LYMPHOCYTES</searchLink><br /><searchLink fieldCode="DE" term="%22MANN+Whitney+U+Test%22">MANN Whitney U Test</searchLink><br /><searchLink fieldCode="DE" term="%22DESCRIPTIVE+statistics%22">DESCRIPTIVE statistics</searchLink><br /><searchLink fieldCode="DE" term="%22BIOMEDICAL+materials%22">BIOMEDICAL materials</searchLink><br /><searchLink fieldCode="DE" term="%22FIBROBLASTS%22">FIBROBLASTS</searchLink><br /><searchLink fieldCode="DE" term="%22IMMUNOHISTOCHEMISTRY%22">IMMUNOHISTOCHEMISTRY</searchLink><br /><searchLink fieldCode="DE" term="%22ANTIGENS%22">ANTIGENS</searchLink><br /><searchLink fieldCode="DE" term="%22STROMAL+cells%22">STROMAL cells</searchLink><br /><searchLink fieldCode="DE" term="%22ENDOTHELIAL+cells%22">ENDOTHELIAL cells</searchLink><br /><searchLink fieldCode="DE" term="%22COLLAGEN%22">COLLAGEN</searchLink><br /><searchLink fieldCode="DE" term="%22DATA+analysis+software%22">DATA analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22CONNECTIVE+tissues%22">CONNECTIVE tissues</searchLink><br /><searchLink fieldCode="DE" term="%22PHENOTYPES%22">PHENOTYPES</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: This article defines immunophenotypes of stromal inflammatory and endothelial cells and fibroblasts 3 months after augmentation of the peri-implant soft tissue using a porcine cross-linked collagen matrix (VCMX). Peri-implant soft tissue samples were obtained from 12 patients at the lining mucosa (LM)-masticatory mucosa (MM) junction before (1) and 3 months after (2) augmentation. Immu-nohistochemical stains were performed to identify inflammatory cells (T [CD3] and B [CD20] lymphocytes, plasma cells [CD138]), macrophages (CD68-proinflammatory, CD163-anti-inflammatory/ reparative), endothelial cells (CD31, CD34), and fibroblasts (CD90, TE-7). Differences in the mean positively stained cells pre- and postaugmentation were analyzed by Wilcoxon signed-rank test. CD31+ endothelial cells showed increased mean numbers in MM2 compared to MM1 (P = .025) and in LM2 compared to LM1 (P = .047). CD163+ anti-inflammatory macrophages showed higher mean numbers in MM2 than in MM1 (P = .021) and in LM2 than in LM1 (P = .012). All other cell phenotypes showed nonsignificant changes between pre- and postaugmentation. This molecular study provides novel insight on the frequency of stromal cell phenotypes in the wound healing process at 3 months postaugmentation with VCMX, with anti-inflammatory CD163+ macrophages being predominant. This should be further investigated to help find novel therapeutic approaches to modulate and promote the VCMX-related healing process. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Periodontics & Restorative Dentistry is the property of Quintessence Publishing Company Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://login.libproxy.scu.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edb&AN=179671939
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.11607/prd.6819
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 11
        StartPage: 601
    Subjects:
      – SubjectFull: IMMUNOPHENOTYPING
        Type: general
      – SubjectFull: MACROPHAGES
        Type: general
      – SubjectFull: TISSUE engineering
        Type: general
      – SubjectFull: ORAL mucosa
        Type: general
      – SubjectFull: LYMPHOCYTES
        Type: general
      – SubjectFull: MANN Whitney U Test
        Type: general
      – SubjectFull: DESCRIPTIVE statistics
        Type: general
      – SubjectFull: BIOMEDICAL materials
        Type: general
      – SubjectFull: FIBROBLASTS
        Type: general
      – SubjectFull: IMMUNOHISTOCHEMISTRY
        Type: general
      – SubjectFull: ANTIGENS
        Type: general
      – SubjectFull: STROMAL cells
        Type: general
      – SubjectFull: ENDOTHELIAL cells
        Type: general
      – SubjectFull: COLLAGEN
        Type: general
      – SubjectFull: DATA analysis software
        Type: general
      – SubjectFull: CONNECTIVE tissues
        Type: general
      – SubjectFull: PHENOTYPES
        Type: general
    Titles:
      – TitleFull: Stromal Cells Associated with Soft Tissue Augmentation by a Volume-Stable Collagen Matrix (VCMX) Are Predominated by Anti-inflammatory/Reparative Macrophages.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Artzi, Zvi
      – PersonEntity:
          Name:
            NameFull: Vered, Marilena
      – PersonEntity:
          Name:
            NameFull: Maymon-Gil, Tal
      – PersonEntity:
          Name:
            NameFull: Renert, Uri
      – PersonEntity:
          Name:
            NameFull: Netanely, Erez
      – PersonEntity:
          Name:
            NameFull: Thoma, Daniel S.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 09
              Text: Sep/Oct2024
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-print
              Value: 01987569
          Numbering:
            – Type: volume
              Value: 44
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: International Journal of Periodontics & Restorative Dentistry
              Type: main
ResultId 1