Bibliographic Details
| Title: |
The Role of Natural Low Molecular Weight Dicarbonyls in Atherogenesis and Diabetogenesis. |
| Authors: |
Lankin, Vadim Z., Tikhaze, Alla K., Sharapov, Mars G., Konovalova, Galina G. |
| Source: |
Reviews in Cardiovascular Medicine; Aug2024, Vol. 25 Issue 8, p1-9, 9p |
| Abstract: |
This review summarises the data from long-term experimental studies and literature data on the role of oxidatively modified low-density lipoproteins (LDL) in atherogenesis and diabetogenesis. It was shown that not “oxidized” (lipoperoxide-containing) LDL, but dicarbonylmodified LDL are atherogenic (actively captured by cultured macrophages with the help of scavenger receptors), and also cause expression of lectin like oxidized low density lipoprotein receptor 1 (LOX-1) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 1 (NOX-1) genes in endotheliocytes, which stimulate apoptosis and endothelial dysfunction. The obtained data allowed us to justify new approaches to pharmacotherapy of atherosclerosis and diabetes mellitus. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
