Bibliographic Details
| Title: |
A Randomized Comparison of Postprandial Glucose Excursion Using Inhaled Insulin Versus Rapid-Acting Analog Insulin in Adults With Type 1 Diabetes Using Multiple Daily Injections of Insulin or Automated Insulin Delivery. |
| Authors: |
Hirsch, Irl B., Beck, Roy W., Marak, Martin Chase, Calhoun, Peter, Mottalib, Adham, Salhin, Amna, Manessis, Anastasios, Coviello, Andrea D., Bhargava, Anuj, Thorsell, Ashley, Atakov Castillo, Astrid, Bode, Bruce W., Levister, Camilla, Levy, Carol J., Donahue, Cassandra, Cordero, Christian, Beatson, Christie, Langel, Christine R., Jacobson, Christopher, Kurek, Corey |
| Source: |
Diabetes Care; Sep2024, Vol. 47 Issue 9, p1682-1687, 6p |
| Subject Terms: |
INSULIN derivatives, TYPE 1 diabetes, BLOOD sugar, INSULIN therapy, INSULIN |
| Abstract: |
OBJECTIVE: To compare postprandial glucose excursions following a bolus with inhaled technosphere insulin (TI) or subcutaneous rapid-acting analog (RAA) insulin. RESEARCH DESIGN AND METHODS: A meal challenge was completed by 122 adults with type 1 diabetes who were using multiple daily injections (MDI), a nonautomated pump, or automated insulin delivery (AID) and who were randomized to bolus with their usual RAA insulin (n = 61) or TI (n = 61). RESULTS: The primary outcome, the treatment group difference in area under the curve for glucose >180 mg/dL over 2 h, was less with TI versus RAA (adjusted difference −12 mg/dL, 95% CI −22 to −2, P = 0.02). With TI, the glucose excursion was smaller (P = 0.01), peak glucose lower (P = 0.01), and time to peak glucose shorter (P = 0.006). Blood glucose <70 mg/dL occurred in one participant in each group. CONCLUSIONS: Postmeal glucose excursion was smaller with TI than with RAA insulin in a cohort that included both AID and MDI users. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
