| Title: |
Childhood and Adolescent Relapsed/Refractory Aggressive B-Cell Lymphomas With t(8;14) and BCL2 Expression, Burkitt Lymphoma Versus Diffuse Large B-Cell Lymphoma: A Diagnostic Challenge. |
| Authors: |
El Dana, Fouad, Garces Narvaez, Sofia Alexandra, El-Mallawany, Nader K., Agrusa, Jennifer E., Dreyer, ZoAnn E., Marcogliese, Andrea N., Elghetany, Mohamed Tarek, Punia, Jyotinder N., Ok, Chi Young, Patel, Keyur P., Lopez-Terrada, Dolores H., Fisher, Kevin E., Curry, Choladda V. |
| Source: |
Pediatric & Developmental Pathology; Jul/Aug2024, Vol. 27 Issue 4, p348-353, 6p |
| Abstract: |
We present 2 diagnostically challenging cases of pediatric/adolescent relapsed/refractory aggressive mature B-cell non-Hodgkin lymphoma (B-NHL) within the spectrum of Burkitt lymphoma and diffuse large B-cell lymphoma and illustrate the different therapeutic regimens that are employed for pediatric and adult cancer centers. Both cases displayed varying-sized lymphoma cells with occasional single prominent nucleoli and heterogeneous BCL2 expression. Cytogenetics revealed complex karyotypes with t(8:14)(q24.2;q32) and IGH::MYC rearrangement by FISH. Next generation sequencing revealed deleterious TP53 and MYC mutations. We concluded that both could be diagnosed as "DLBCL-NOS with MYC rearrangement" using the current pathologic classifications, 2022 International Consensus Classification (ICC) and World Health Organization Classifications of Haematolymphoid Tumors (WHO-HAEM5). This report illustrates diagnostic challenges and treatment dilemmas that may be encountered, particularly for adolescent and young adults (AYA). [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
