Bibliographic Details
| Title: |
DBU‐Catalyzed Vinylogous Reaction of 3‐Cyano‐4‐methylcoumarins with 3‐Arylsulfonyl‐3‐indolyloxindoles. |
| Authors: |
Mritunjay, Sharma, Shubham, Singh, Pushpinder, Gupta, Ankush, Singh, Virender, Singh, Lakhmir, Kumar, Akshay |
| Source: |
ChemistrySelect; 8/12/2024, Vol. 9 Issue 30, p1-5, 5p |
| Subject Terms: |
DRUG development, ORGANOCATALYSIS, MOIETIES (Chemistry), MOLECULES, CARBON |
| Abstract: |
An efficient metal‐free DBU catalyzed approach for the construction of biologically significant quaternary carbon centered C‐3 functionalized 2‐oxindole derivatives through vinylogous reaction of 3‐cyano‐4‐methylcoumarins with 3‐arylsulfonyl‐3‐indolyloxindoles has been developed for first time. The developed protocol is simple, cost‐effective, and producing the desired products in good yields, without utilizing potentially harmful chemicals. Moreover, the synthesized 3,3‐disubstituted 2‐oxindole molecules contain established pharmacophors in their structure, i. e. oxindole‐, indole‐ and coumarin‐ moieties, which makes them a valuable candidate for drug development process. [ABSTRACT FROM AUTHOR] |
|
Copyright of ChemistrySelect is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
