Bibliographic Details
| Title: |
Arginine vasopressin deficiency onset after COVID-19 vaccination with positive anti-rabphilin-3A antibodies: a case report and literature review. |
| Authors: |
Takizawa, Hiroki, Goto, Hiromasa, Uchida, Toyoyoshi, Aoyama, Shuhei, Fujisawa, Haruki, Iwata, Naoko, Suzuki, Atsushi, Sugimura, Yoshihisa, Watada, Hirotaka |
| Source: |
BMC Endocrine Disorders; 8/6/2024, Vol. 24 Issue 1, p1-7, 7p |
| Subject Terms: |
VASOPRESSIN, IMMUNIZATION, DIFFERENTIAL diagnosis, PITUITARY gland, COVID-19 vaccines, MAGNETIC resonance imaging, AGE factors in disease, MONOCLONAL antibodies, POLYURIA, INFLAMMATION, POLYDIPSIA |
| Abstract: |
Background: Arginine vasopressin deficiency (AVP-D) can occur due to various conditions, so clarifying its cause is important for deciding treatment strategy. Although several cases of AVP-D following coronavirus disease 2019(COVID-19) infection or COVID-19 vaccination have been reported, the diagnosis of the underlying disease has not been reported in most cases. Case presentation: A 75-year-old woman who presented with polydipsia and polyuria 9 weeks after contracting COVID-19 and 5 weeks after receiving the SARS-CoV-2 vaccination, leading to the final diagnosis of AVP-D 8 months after the first appearance of symptoms. Interestingly, pituitary magnetic resonance imaging (MRI) still revealed stalk enlargement frequently observed in patients with SARS-CoV-2 vaccination-induced AVP-D. Although this finding could not rule out any malignancies, we additionally measured anti-rabphilin-3A antibodies, a known marker for lymphocytic infundibulo-neurohypophysitis (LINH), and found that the results were positive, strongly suggesting LINH as the cause of this disease. Thus, we avoided pituitary biopsy. At the follow-up MRI conducted 12 months after the initial consultation, enlargement of the pituitary stalk was still observed. Conclusion: We experienced a case with LINH probably induced by SARS-CoV-2 vaccination. In SARS-CoV-2 vaccination-related LINH, unlike typical LINH, there is a possibility of persistent pituitary stalk enlargement on MRI images for an extended period, posing challenges in differential diagnosis from other conditions. Pituitary stalk enlargement and positive anti-rabphilin-3A antibodies may help in the diagnosis of AVP-D induced by SARS-CoV-2 vaccination. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
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