Bibliographic Details
| Title: |
Screening for central precocious puberty by single basal Luteinizing Hormone levels. |
| Authors: |
Li Pomi, Alessandra, Scalini, Perla, De Masi, Salvatore, Corica, Domenico, Pepe, Giorgia, Wasniewska, Malgorzata, Stagi, Stefano |
| Source: |
Endocrine (1355008X); Aug2024, Vol. 85 Issue 2, p955-963, 9p |
| Abstract: |
Purpose: To identify cut-off for basal LH levels and for pelvic ultrasound uterine and ovarian parameters indicating an Hypotalamic–Pituitary–Gonadal (HPG) axis activation as diagnostic of Central Precocious Puberty (CPP). Methods: 248 girls referred for suspected precocious/early puberty who had undergone a GnRH stimulation test were enrolled and divided into three groups: Premature Idiopathic Thelarche (PIT), CPP, and Early Puberty (EA). For every patient basal serum Luteinising Hormone (LH) and Follicle Stimulating Hormone (FSH), basal LH/FSH ratio and pelvic ultrasonographic parameters were also collected. Through the use of Receiver Operating Curves (ROCs) the sensitivity (Se) and specificity (Sp) of basal LH, FSH, LH/FSH ratio and ultrasonographic parameters were evaluated at each level and Area Under the Curve (AUC) was measured. Results: Basal LH model ≥0.14 mIU/mL reached the highest predictability (90.6% and 78.2%, Se and Sp, respectively). Basal LH/FSH ratio ≥0.1 showed a sensitivity of 85.90% and a specificity of 78.14%, while basal FSH cut-off (≥2.36 mIU/mL) had the lowest predictability, with a less favourable sensitivity (71%) and specificity (70.5%). Cut-off point for uterine length as 35 mm, (83.5% and 42.9% of Se and Sp, respectively) was calculated. For ovarian volumes, ROC curves showed very low sensitivity and specificity. Conclusion: A single basal LH measurement under the cut-off limit may be adequate to exclude an HPG axis activation as CPP. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
