Bibliographic Details
| Title: |
UVB-Aged Microplastics and Cellular Damage: An in Vitro Study. |
| Authors: |
La Maestra, Sebastiano, Benvenuti, Mirko, Alberti, Stefano, Ferrea, Linda, D'Agostini, Francesco |
| Source: |
Archives of Environmental Contamination & Toxicology; Jul2024, Vol. 87 Issue 1, p48-57, 10p |
| Subject Terms: |
MICROPLASTICS, FOURIER transform infrared spectroscopy, MECHANICAL abrasion, MICROORGANISM populations, PLASTICS, POLYSTYRENE, MALONDIALDEHYDE |
| Abstract: |
Plastics are synthetic organic compounds whose widespread use generates enormous waste. Different processes, such as mechanical abrasion, microbiological activity, and UVB irradiation, can fragment the plastic material and generate microplastics (MPs). MPs are ubiquitous, and various organisms, including humans, can ingest or inhale them, with potential adverse health effects. The differences between UV-aged and virgin particles were studied to evaluate the genotoxic damage and oxidative stress induced by polystyrene MPs with 1 and 5 µm sizes on the monocyte-like cell line (THP-1). Fourier transform infrared spectroscopy and Ζ-potential measurements were used to characterise MP particles after UVB exposure. Cells exposed to MPs show a widespread change in the cellular environment with the generation of reactive oxidative species (ROS), as indicated by the increased malondialdehyde level. The occurrence of genotoxic damage is correlated to the smaller size and ageing state of the MPs. The biochemical and genomic alterations observed in this in vitro study suggest that MPs, ubiquitous pollutants, following natural degradation and oxidation processes can cause various adverse effects on the health of the exposed population, making it necessary to carry out further studies to better define the real risk. [ABSTRACT FROM AUTHOR] |
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| Database: |
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