Bibliographic Details
| Title: |
Stability and plasticity of regulatory T cells in health and disease. |
| Authors: |
Contreras-Castillo, Eugenio, García-Rasilla, Verónica Yutsil, García-Patiño, María Guadalupe, Licona-Limón, Paula |
| Source: |
Journal of Leukocyte Biology; Jul2024, Vol. 116 Issue 1, p33-53, 21p |
| Subject Terms: |
REGULATORY T cells, TRANSCRIPTION factors |
| Abstract: |
The mechanisms that negatively regulate inflammation upon a pathogenic stimulus are crucial for the maintenance of tissue integrity and organ function. T regulatory cells are one of the main drivers in controlling inflammation. The ability of T regulatory cells to adapt to different inflammatory cues and suppress inflammation is one of the relevant features of T regulatory cells. During this process, T regulatory cells express different transcription factors associated with their counterparts, Th helper cells, including Tbx21 , GATA-3 , Bcl6 , and Rorc. The acquisition of this transcription factor helps the T regulatory cells to suppress and migrate to the different inflamed tissues. Additionally, the T regulatory cells have different mechanisms that preserve stability while acquiring a particular T regulatory cell subtype. This review focuses on describing T regulatory cell subtypes and the mechanisms that maintain their identity in health and diseases. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
