Bibliographic Details
| Title: |
Engineering self-catabolic DNAzyme nanospheres for synergistic anticancer therapy. |
| Authors: |
Chen, Yu, Guo, Yu, Wang, Jiaoli, Liu, Ruiting, Yang, Xiaohai, Wang, Kemin, Pu, Ying, Shi, Hui, Huang, Jin |
| Source: |
SCIENCE CHINA Chemistry; Jul2024, Vol. 67 Issue 7, p2412-2422, 11p |
| Abstract: |
DNAzyme-based gene therapy faces some challenges including cell penetration, activity limitation, and co-delivery functions. Self-assembled DNA nanomedicine has attracted widespread attention due to its many advantages. It is urgent to develop a universal DNA degradation strategy for precise programmable drug release. Herein, we reported a self-catabolic DNAzyme nanospheres (SCNS), which could simultaneously achieve cell penetration, activity enhancement, and co-delivery functions. The SCNS were assembled through Y-DNA stepwise hybridization with each other, which were then loaded with aptamer (Apt), doxorubicin (Dox), and zinc oxide nanoparticles (ZnO NPs). The acid-triggered dissociation of ZnO NPs leads to the generation of Zn2+ ions cofactors for immediately self-catabolic DNAzyme nanospheres. After the disassembly of the SCNS, three types of anticancer treatments would be activated, which include Zn2+ involved reactive oxygen species (ROS), Dox-induced chemotherapy, and DNAzyme-based gene therapy. The experimental results show that the nanoplatform (Apt-SCNS-Dox-ZnO) has a good tumor-killing effect and minimal side effects. As a smart self-driven drug delivery nanoplatform, it is anticipated to displace extraordinary potential in biomedicine and bioengineering. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
