Bibliographic Details
| Title: |
Evidence That Peripheral Leptin Resistance in Omental Adipose Tissue and Liver Correlates with MASLD in Humans. |
| Authors: |
De la Cruz-Color, Lucia, Dominguez-Rosales, Jose Alfredo, Maldonado-González, Montserrat, Ruíz-Madrigal, Bertha, Sánchez Muñoz, Martha P., Zaragoza-Guerra, Vianney Alejandrina, Espinoza-Padilla, Victor H., Ruelas-Cinco, Elizabeth del C., Ramírez-Meza, Sandra M., Torres Baranda, José R., González-Gutiérrez, María del R., Hernandez Nazara, Zamira Helena |
| Source: |
International Journal of Molecular Sciences; Jun2024, Vol. 25 Issue 12, p6420, 22p |
| Subject Terms: |
PHOSPHOLIPASES, TRANSCRIPTION factors, ADIPOSE tissues, LEPTIN, SUPPRESSORS of cytokine signaling, LEPTIN receptors, INSULIN sensitivity, NON-alcoholic fatty liver disease |
| Abstract: |
Leptin regulates lipid metabolism, maximizing insulin sensitivity; however, peripheral leptin resistance is not fully understood, and its contribution to metabolic dysfunction-associated steatotic liver disease (MASLD) is unclear. This study evaluated the contribution of the leptin axis to MASLD in humans. Forty-three participants, mostly female (86.04%), who underwent cholecystectomy were biopsied. Of the participants, 24 were healthy controls, 8 had MASLD, and 11 had metabolic dysfunction-associated steatohepatitis (MASH). Clinical and biochemical data and the gene expression of leptin, leptin receptor (LEPR), suppressor of cytokine signaling 3 (SOCS3), sterol regulatory element-binding transcription factor 1 (SREBF1), stearoyl-CoA desaturase-1 (SCD1), and patatin-like phospholipase domain-containing protein 2 (PNPLA2), were determined from liver and adipose tissue. Higher serum leptin and LEPR levels in the omental adipose tissue (OAT) and liver with MASH were found. In the liver, LEPR was positively correlated with leptin expression in adipose tissue, and SOCS3 was correlated with SREBF1-SCD1. In OAT, SOCS3 was correlated with insulin resistance and transaminase enzymes (p < 0.05 for all. In conclusion, we evidenced the correlation between the peripheral leptin resistance axis in OAT–liver crosstalk and the complications of MASLD in humans. [ABSTRACT FROM AUTHOR] |
|
Copyright of International Journal of Molecular Sciences is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
|
Full text is not displayed to guests. |
Login for full access.
|
