Bibliographic Details
| Title: |
AKR1A1 and Kidney Disease: Promise and Perils of the Multiverse. |
| Authors: |
Breyer, Matthew D. |
| Source: |
Diabetes; Jul2024, Vol. 73 Issue 7, p1046-1047, 2p |
| Subject Terms: |
KIDNEY diseases, GENE expression, GENETIC variation, LOCUS (Genetics), KIDNEY cortex |
| Abstract: |
A recent study published in the journal Diabetes suggests that a polymorphism in the AKR1A1 gene may be associated with diabetic kidney disease (DKD). The study used transcriptomics and proteomics data to identify concordant gene-protein pairs that were changed in a similar direction with DKD. However, it is unclear whether altered protein expression is a cause or effect of DKD. The study also found that the AKR1A1 polymorphism is associated with increased serum cystatin C, a marker of glomerular filtration rate. Further research is needed to understand the role of AKR1A1 in DKD and identify potential therapeutic targets. [Extracted from the article] |
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| Database: |
Complementary Index |
