Bibliographic Details
| Title: |
Anti-SARS-CoV-2 Spike Antibody Response to the Fourth Dose of BNT162b2 mRNA COVID-19 Vaccine and Associated Factors in Japanese Hemodialysis Patients. |
| Authors: |
Hirai, Keiji, Shimotashiro, Masako, Okumura, Toshiaki, Ookawara, Susumu, Morishita, Yoshiyuki |
| Source: |
International Journal of Nephrology & Renovascular Disease; May2024, Vol. 17, p135-149, 15p |
| Subject Terms: |
SARS-CoV-2, ANTIBODY formation, ANTIBODY titer, COVID-19 vaccines, HEMODIALYSIS patients |
| Abstract: |
Background: We assessed the anti-SARS-CoV-2 spike antibody response to four doses of BNT162b2 mRNA COVID-19 vaccine in Japanese hemodialysis patients and determined factors associated with the anti-SARS-CoV-2 spike antibody titer after the fourth dose. Methods: Fifty-one patients were enrolled in this single-center, prospective, longitudinal study. Change in anti-SARS-CoV-2 spike antibody titers between after the second and fourth doses were evaluated. Multiple linear regression analysis was used to identify factors associated with the anti-SARS-CoV-2 spike antibody titer after the fourth dose. Results: The anti-SARS-CoV-2 spike antibody titer was higher 4 weeks after the fourth dose compared with 4 weeks after the third dose (30,000 [interquartile range (IQR), 14,000– 56,000] vs 18,000 [IQR, 11,000– 32,500] AU/mL, p< 0.001) and 4 weeks after the second dose (vs 2896 [IQR, 1110– 4358] AU/mL, p< 0.001). Hypoxia-inducible factor prolyl hydroxylase inhibitor use (standard coefficient [β]=0.217, p=0.011), and the log-anti-SARS-CoV-2 spike antibody titer 1 week before the fourth dose (β=0.810, p< 0.001) were correlated with the log-anti-SARS-CoV-2 spike antibody titer 4 weeks after the fourth dose, whereas only the log-anti-SARS-CoV-2 spike antibody titer 1 week before the fourth dose (β=0.677, p< 0.001) was correlated with the log-anti-SARS-CoV-2 spike antibody titer 12 weeks after the fourth dose. Conclusion: Hypoxia-inducible factor prolyl hydroxylase inhibitor use and the anti-SARS-CoV-2 spike antibody titer before the fourth dose were associated with the anti-SARS-CoV-2 spike antibody titer after the fourth dose in Japanese hemodialysis patients. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
