| Title: |
The Effect of Open-Label Semaglutide on Metabolic Dysfunction–Associated Steatotic Liver Disease in People With HIV. |
| Authors: |
Lake, Jordan E., Kitch, Douglas W., Kantor, Amy, Muthupillai, Raja, Klingman, Karin L., Vernon, Christina, Belaunzaran-Zamudio, Pablo F., Fichtenbaum, Carl J., Heath, Sonya, Perazzo, Hugo, Corey, Kathleen, Brown, Todd T., Landay, Alan, Sattler, Fred, Erlandson, Kristine M. |
| Source: |
Annals of Internal Medicine; Jun2024, Vol. 177 Issue 6, p835-838, 11p |
| Subject Terms: |
FATTY liver, LIVER diseases, HIV-positive persons, HEPATITIS C, SEMAGLUTIDE |
| Abstract: |
This article explores the impact of open-label semaglutide on metabolic dysfunction-associated steatotic liver disease (MASLD) in individuals with HIV. MASLD is a condition characterized by fatty liver disease and cardiovascular disease risk factors. The study aimed to determine if semaglutide could reduce liver fat and improve cardiometabolic parameters in people with HIV and MASLD. The findings indicate that semaglutide effectively reduces liver fat and improves markers such as glucose regulation and triglyceride concentrations. Participants generally tolerated semaglutide well, with mild gastrointestinal symptoms being the most common adverse events. While the study has limitations, such as a small sample size and the absence of a control group, it suggests that semaglutide may be a promising treatment for MASLD in individuals with HIV, potentially offering broader cardiometabolic benefits. [Extracted from the article] |
|
Copyright of Annals of Internal Medicine is the property of American College of Physicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
