Bibliographic Details
| Title: |
Clinical and Bacteriological Specificities of Escherichia coli Bloodstream Infections From Biliary Portal of Entries. |
| Authors: |
Sokal, Aurélien, Royer, Guilhem, Esposito-Farese, Marina, Clermont, Olivier, Condamine, Bénédicte, Laouénan, Cedric, Lefort, Agnès, Denamur, Erick, Lastours, Victoire de, Groups, for the Colibafi Septicoli and Coliville |
| Source: |
Journal of Infectious Diseases; 6/15/2024, Vol. 229 Issue 6, p1679-1687, 9p |
| Subject Terms: |
ESCHERICHIA coli diseases, SEPTIC shock, DRUG resistance in bacteria, ESCHERICHIA coli |
| Abstract: |
Background Escherichia coli is frequently responsible for bloodstream infections (BSIs). Among digestive BSIs, biliary infections appear to be less severe. Respective roles of host factors, bacterial determinants (phylogroups, virulence, and antibiotic resistance), and portal of entry on outcome are unknown. Methods Clinical characteristics and prognosis of 770 episodes of E coli BSI were analyzed and isolates sequenced (Illumina technology) comparing phylogroups, multilocus sequence type, virulence, and resistance gene content. BSI isolates were compared with 362 commensal E coli from healthy subjects. Results Among 770 episodes, 135 were biliary, 156 nonbiliary digestive, and 479 urinary. Compared to urinary infections, BSIs of digestive origin occurred significantly more in men, comorbid, and immunocompromised patients. Digestive portal of entry was significantly associated with septic shock and death. Among digestive infections, patients with biliary infections were less likely to die (P =.032), despite comparable initial severity. Biliary E coli resembled commensals (phylogroup distribution, sequence type, and few virulence-associated genes) whereas nonbiliary digestive and urinary strains carried many virulence-associated genes. Conclusions Escherichia coli strains responsible for biliary infections exhibit commensal characteristics and are associated with lower mortality rates, despite similar initial severity, than other digestive BSIs. Biliary drainage in addition to antibiotics in the management of biliary infections may explain improved outcome. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
