Bibliographic Details
| Title: |
Ultrasound, Histomorphologic, and Immunohistochemical Analysis of a Cardiac Tumor with Increased Purkinje Cells Detected in a Canine Fetus 42 Days into Pregnancy. |
| Authors: |
Giordano, Enrico, Ponticelli, Ignazio, Attard, Simona, Pagano, Teresa Bruna, Pisu, Maria Carmela |
| Source: |
Veterinary Sciences; May2024, Vol. 11 Issue 5, p216, 9p |
| Subject Terms: |
PURKINJE cells, FETUS, IMMUNOHISTOCHEMISTRY, AUTOPSY, PREGNANCY, VETERINARY medicine, CELL tumors |
| Abstract: |
Simple Summary: This study examined a case of cardiac tumor with increased Purkinje cells found in the heart of a neonate dog, a condition primarily observed in humans and swine. During a pregnancy ultrasound involving a Chow Chow, a mass was detected in one fetus's heart, resulting in the birth of a stillborn neonate. Post-mortem examinations revealed the poorly demarcated mass. Histology and immunohistochemistry revealed a complex mass with Purkinje cells that were increased in number and concentrated in perivascular areas. This study emphasizes the uniqueness of diagnosing a cardiac tumor in a dog fetus during pregnancy. Furthermore, the description of a Purkinje cell-rich cardiac tumor is extremely rare in the veterinary literature. The findings of this study draw parallels between Purkinje cell tumors in dogs and those observed in humans, swine, bearded seals, bovine, and deer. A seven-year-old healthy female Chow Chow was referred for pregnancy monitoring. Ultrasonography was used to evaluate all pregnancy and fetus parameters, and they were found to be normal. During the examination of the 42 day pregnant bitch, an unusual mass was seen in a fetus's heart. This fetus had a cardiac frequency of 273–300 beats, while the others had heart rates of 220–240 beats. Natural vaginal birth occurred at 63 days pregnant: the first two puppies were stillborn but perfectly formed, and the other three were alive and had optimal APGAR. In one of two deceased puppies, an unusual, reddish, smooth mass occupying the space in the heart was found through necroscopy. The organ was submitted for histological examination. Histopathology, immunohistochemical, and histochemical analyses all indicated a cardiac tumor with increased Purkinje cells. This type of tumor has been described in infants, swine, bearded seals, and deer but never in fetuses and neonates of dogs. To our knowledge, this is the first such case reported in veterinary medicine. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
