Bibliographic Details
| Title: |
How murine neutrophils are hijacked within the microenvironment of pancreatic cancer. |
| Authors: |
Cassatella, Marco Antonio, Scapini, Patrizia, Tamassia, Nicola |
| Source: |
Journal of Leukocyte Biology; Apr2024, Vol. 115 Issue 4, p585-588, 4p |
| Subject Terms: |
PANCREATIC tumors, PANCREATIC cancer, NEUTROPHILS, TUMOR microenvironment, PANCREATIC duct, TUMOR growth |
| Abstract: |
Discoveries made in the past decades have brought out that, in addition to their classical primary defensive functions against infections, polymorphonuclear neutrophils play key effector roles not only in chronic inflammatory and immune-mediated diseases but also in cancer. In addition, depending on their differentiation/activation status and/or on the physiological or pathological microenvironment in which they reside, neutrophils have been shown to behave as highly plastic cells, able to acquire new phenotypes/functional states. All these features are well manifested in cancer and modulated during tumor progression. Herein, we discuss intriguing data by Lai Ng's group that have shed light on the origin and development of terminally differentiated, proangiogenic, tumor-associated neutrophils, facilitating tumor growth in a murine orthotopic model of pancreatic ductal adenocarcinoma. These findings help to progress toward the ambitious goal of selectively targeting only the skewed pathological neutrophil populations present within the tumor microenvironment. This News and Views article comments on recent data demonstrating that murine neutrophils, upon tumor entry, are reprogrammed into a final population able to prolong their survival and promote neovascularization (https://doi.org/10.1126/science.adf6493). [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Leukocyte Biology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
