Bibliographic Details
| Title: |
Blastoid Variant Mantle Cell Lymphoma with Amplified IGH/CCND1 Fusion: A Unique Case and Current Literature Review. |
| Authors: |
Goktas, Emine, Sanal, Sumeyye, Esen, Haci Hasan, Tekinalp, Atakan |
| Source: |
Medical Bulletin of Haseki / Haseki Tip Bulteni; Mar2024, Vol. 62 Issue 2, p124-127, 4p |
| Subject Terms: |
THERAPEUTIC use of antineoplastic agents, BIOPSY, BLADDER tumors, NON-Hodgkin's lymphoma, PAPILLARY carcinoma, COMPUTED tomography, ANTINEOPLASTIC agents, TUMOR lysis syndrome, CHROMOSOME abnormalities, RITUXIMAB, BLOOD cell count, TREATMENT effectiveness, IMMUNOHISTOCHEMISTRY, FLUORESCENCE in situ hybridization, ONCOLOGISTS, MEDICAL referrals, COLONOSCOPY, GENETIC testing, DISEASE complications |
| Abstract: |
Mantle cell lymphoma (MCL) is a subtype of mature B-cell non-Hodgkin lymphoma (NHL). Most cases exhibit CCDN1/IGH translocation; however, reports indicate that amplification of the fusion gene is extremely rare. A 72-year-old male patient diagnosed with an MCL blastoid variant was referred to us. Amplified CCDN1(11q13)/IGH(14q32.3) fusion genes were observed in 75% of the interphase nuclei of the patient. We present the first case of blastoid variant MCL with multiple IGH/CCND1 fusion signals by interphase fluorescence in situ hybridization. Our patient exhibited an aggressive course and passed away on the second day of treatment. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
