Bibliographic Details
| Title: |
Comparison of two frailty definitions in women with systemic lupus erythematosus. |
| Authors: |
Lieber, Sarah B, Nahid, Musarrat, Legge, Alexandra, Rajan, Mangala, Lipschultz, Robyn A, Lin, Myriam, Reid, M Carrington, Mandl, Lisa A |
| Source: |
Rheumatology; May2024, Vol. 63 Issue 5, p1384-1390, 7p |
| Subject Terms: |
CROSS-sectional method, SELF-evaluation, RESEARCH funding, DISEASE duration, FRAIL elderly, SYSTEMIC lupus erythematosus, SEVERITY of illness index, DISEASE prevalence, DESCRIPTIVE statistics, ODDS ratio, STATISTICS, WOMEN'S health, HEALTH outcome assessment, COMPARATIVE studies, CONFIDENCE intervals, PHENOTYPES, EVALUATION, DISEASE complications |
| Geographic Terms: |
UNITED States |
| Abstract: |
Objectives Frailty is a risk factor for adverse health in SLE. The Fried phenotype (FP) and the SLICC Frailty Index (SLICC-FI) are common frailty metrics reflecting distinct approaches to frailty assessment. We aimed to (1) compare frailty prevalence according to both metrics in women with SLE and describe differences between frail and non-frail participants using each method and (2) evaluate for cross-sectional associations between each metric and self-reported disability. Methods Women aged 18–70 years with SLE were enrolled. FP and SLICC-FI were measured, and agreement calculated using a kappa statistic. Physician-reported disease activity and damage, Patient Reported Outcome Measurement Information System (PROMIS) computerized adaptive tests, and Valued Life Activities (VLA) self-reported disability were assessed. Differences between frail and non-frail participants were evaluated cross-sectionally, and the association of frailty with disability was determined for both metrics. Results Of 67 participants, 17.9% (FP) and 26.9% (SLICC-FI) were frail according to each metric (kappa = 0.41, P < 0.01). Compared with non-frail women, frail women had greater disease damage, worse PROMIS scores, and greater disability (all P < 0.01 for FP and SLICC-FI). After age adjustment, frailty remained associated with a greater odds of disability [FP: odds ratio (OR) 4.7, 95% CI 1.2, 18.8; SLICC-FI: OR 4.6, 95% CI 1.3, 15.8]. Conclusion Frailty is present in 17.9–26.9% of women with SLE. These metrics identified a similar, but non-identical group of women as frail. Further studies are needed to explore which metric is most informative in this population. [ABSTRACT FROM AUTHOR] |
|
Copyright of Rheumatology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
