| Title: |
45S5/PEEK Coatings by Cold Gas Spray with In Vitro Bioactivity, Degradation, and Cellular Proliferation. |
| Authors: |
Garrido, Beatriz, Albaladejo-Fuentes, Vicente, Dosta, Sergi, Garcia-Giralt, Natalia, Garcia-Cano, Irene |
| Source: |
Journal of Thermal Spray Technology; Apr2024, Vol. 33 Issue 4, p895-911, 17p |
| Subject Terms: |
BIOACTIVE glasses, INDUCTIVELY coupled plasma atomic emission spectrometry, COLD gases, CELL proliferation, GLASS coatings, SURFACE coatings |
| Abstract: |
This study evaluated the biological response of cold-sprayed coatings composed of bioactive glass 45S5 and polyetheretherketone (PEEK). The functional coatings were produced by cold gas spray (CGS) technology, a technique that allows the deposition of powders at significantly low temperatures, avoiding heat damage to polymeric surfaces. By CGS, blends with different ratios of bioactive glass and PEEK powders have been deposited onto PEEK substrates to improve the response of the bio-inert polymer. The bioactivity of the coatings when immersed in a simulated body fluid solution was evaluated by observation with scanning electron microscopy (SEM) and x-ray diffraction (XRD). Results verify that bioactive glass particles in the composite coatings enhance their bioactivity. A degradation test was performed with Tris–HCl solution. From the results obtained by inductively coupled plasma optical emission spectroscopy (ICP-OES) and the weight loss of the samples, it was noticed that the degradation was directly related to the amount of glass in the coatings. Finally, the ability of bone-forming cells to adhere and proliferate on the coatings was evaluated. These experiments showed that the presence of glass particles does not cause a significant increase in cell proliferation. Combining a bioactive material with PEEK leads to forming a final component that provides suitable bioactivity to the final implant. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
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