Bibliographic Details
| Title: |
Optimization of poly(Ε-caprolactone) based biodegradable in situ porous drug-eluting insert of BCS class II/IV drug for targeted application. |
| Authors: |
Patel, Riya, Shah, Umang, Patel, Gayatri |
| Source: |
International Journal of Polymeric Materials & Polymeric Biomaterials; 2024, Vol. 73 Issue 10, p885-896, 12p |
| Subject Terms: |
CONTROLLED release drugs, PATIENT compliance, CLOTRIMAZOLE, POLYCAPROLACTONE |
| Abstract: |
Over the past decades, comprehensive attempts have been made to improve physiological absorption by designing delivery systems, using suitable carriers, and altering the route of administration. Here, the vaginal route was targeted using capsular-shaped biodegradable in situ porous drug-eluting inserts (DEI) using clotrimazole as a model drug and PCL and PEO WSR 303 as rate-controlling polymers. Morphology, thermal properties, and degradation kinetics were assessed in comparison to non-porous DEI. The optimized DEI showed site-specific controlled drug release as per disease need, which may lead to enhanced bioavailability as well as patient compliance with reduced dose-related side effects. [ABSTRACT FROM AUTHOR] |
|
Copyright of International Journal of Polymeric Materials & Polymeric Biomaterials is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
